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Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
Also Known As:
Ubiquitin-Protein Ligase; E3 Ligase; E3 Ubiquitin Ligase; Ubiquitin Ligase E3; Ubiquitin-Protein Ligase E3; Ligase E3, Ubiquitin; Ligase E3, Ubiquitin-Protein; Ligase, E3; Ligase, E3 Ubiquitin; Ligase, Ubiquitin-Protein; Ligases, Ubiquitin-Protein; Ubiquitin Ligase, E3; Ubiquitin Protein Ligase; Ubiquitin Protein Ligase E3; Ubiquitin Protein Ligases
Networked: 3432 relevant articles (30 outcomes, 246 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wei, Wenyi: 27 articles (01/2022 - 09/2010)
2. Sun, Yi: 26 articles (06/2022 - 07/2003)
3. Liu, Wei: 14 articles (11/2022 - 06/2015)
4. Ohh, Michael: 14 articles (11/2021 - 03/2003)
5. Penninger, Josef M: 14 articles (01/2021 - 02/2005)
6. Zhang, Jian: 14 articles (12/2020 - 04/2008)
7. Wang, Chenji: 13 articles (01/2022 - 10/2011)
8. Wang, Jing: 13 articles (01/2022 - 02/2015)
9. Zhang, Wei: 13 articles (01/2022 - 08/2015)
10. Li, Wei: 12 articles (01/2022 - 01/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Pancreatic Neoplasms (Pancreatic Cancer)
4. Hematologic Neoplasms (Hematological Malignancy)
5. Neoplasm Metastasis (Metastasis)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Ubiquitin
3. Phosphotransferases (Kinase)
4. 3- (5- amino- 2- methyl- 4- oxoquinazolin- 3(4H)- yl)piperidine- 2,6- dione
5. pevonedistat
6. Immunomodulating Agents
7. Thalidomide (Thalomid)
8. Enzymes
9. Proteasome Endopeptidase Complex (Proteasome)
10. Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1. Therapeutics
2. Adjuvant Radiotherapy
3. Drug Therapy (Chemotherapy)
4. Immunotherapy
5. Radiotherapy