Werner Syndrome Helicase

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Aggarwal, Monika: 2 articles (09/2013 - 01/2011)
2.	Brosh, Robert M: 2 articles (09/2013 - 01/2011)
3.	Shoemaker, Robert H: 2 articles (09/2013 - 01/2011)
4.	Sommers, Joshua A: 2 articles (09/2013 - 01/2011)
5.	Huang, Kai: 1 article (09/2019)
6.	Jiang, Pengpeng: 1 article (09/2019)
7.	Liu, Dujuan: 1 article (09/2019)
8.	Liu, Xingcun: 1 article (09/2019)
9.	Ma, Paul: 1 article (09/2019)
10.	Tang, Tom: 1 article (09/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "The Werner Syndrome helicase, WRN, is a promising therapeutic target in cancers with microsatellite instability (MSI). " 01/01/2022 - "We have utilized these approaches to characterize the role of the Werner syndrome helicase (WRN) to protect replication forks in cells that are deficient in the tumor suppressor and genome stability factor BRCA2." 03/29/2019 - "Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability." 01/01/2019 - "We verified one of our most promising dependencies, the Werner syndrome ATP-dependent helicase, as a synthetic lethal target in tumours from multiple cancer types with microsatellite instability. " 01/01/2019 - "By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells. "
2.	Microsatellite Instability 01/01/2023 - "The Werner Syndrome helicase, WRN, is a promising therapeutic target in cancers with microsatellite instability (MSI). " 03/29/2019 - "Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability." 01/01/2019 - "We verified one of our most promising dependencies, the Werner syndrome ATP-dependent helicase, as a synthetic lethal target in tumours from multiple cancer types with microsatellite instability. " 01/01/2019 - "By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells. " 01/01/2019 - "Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells."
3.	Genomic Instability 07/24/2015 - "The Werner syndrome helicase (WRN) plays a role in maintaining genomic stability. " 01/01/2022 - "We have utilized these approaches to characterize the role of the Werner syndrome helicase (WRN) to protect replication forks in cells that are deficient in the tumor suppressor and genome stability factor BRCA2." 09/15/2000 - "After treatment with Werner DNA helicase the TRDC dissociated into smaller fragments, provided that human replication protein A was present, indicating that: (i) the TRDC is a new substrate for the Werner syndrome helicase; (ii) the telomere repeat sequence re-anneals rapidly unless unwound single-stranded regions are protected by replication protein A; (iii) the TRDC may provide a new clue to understanding deleterious telomere-totelomere interactions that can lead to genomic instability. "
4.	Carcinogenesis 03/01/2011 - "The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice." 09/02/2005 - "Here, we report that NDH II interacts with the Werner syndrome helicase WRN, an enzyme associated with premature aging and predisposition to tumorigenesis. "
5.	Premature Aging 01/25/2011 - "An in vitro helicase activity screen was used to identify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature aging disorder Werner syndrome. " 09/02/2005 - "Here, we report that NDH II interacts with the Werner syndrome helicase WRN, an enzyme associated with premature aging and predisposition to tumorigenesis. "

Related Drugs and Biologics

1.	Decorin
2.	Replication Protein A
3.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
4.	Proteins (Proteins, Gene)
5.	Plasminogen Activators (Plasminogen Activator)
6.	Phosphoric Monoester Hydrolases (Phosphatases)
7.	Nucleotides
8.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
9.	Exonucleases (3' 5' Exonuclease)
10.	Enzymes

Related Therapies and Procedures

1.	Aftercare (After-Treatment)