Premature Aging

01/01/2007 - "Moreover, diet supplementation with antioxidants showed to be an effective strategy for protection against early immune and behavioral decline, altered redox state of leukocytes and premature mortality in PAM, which supports the validity of this model of premature aging as well as its link with oxidative stress."
12/01/2023 - "Because much of the damage results from oxidative stress, we examined the effects of a topical composition containing three antioxidants in an in vitro model system to assess the potential for amelioration of premature aging. "
01/01/2019 - "Thus, despite extensive functional wiring of mitostatic and antioxidant/proteostatic modules, sustained loss-of mitostasis exhausts adaptation responses triggering premature aging."
11/01/2016 - "Antioxidant Treatment Improves Cardiac Dysfunction in a Murine Model of Premature Aging."
06/02/2016 - "Repression of the Antioxidant NRF2 Pathway in Premature Aging."

11/10/2020 - "Our findings spotlight proteins with increased abundance, as compared to the untreated cell culture counterparts at the same timepoints, that were related to preventing premature aging, homeostasis, tissue regeneration, protection against ultraviolet radiation and oxidative damage."
11/01/2022 - "In this study, exome sequencing in a sixteen-year-old male with manifestations of premature aging led to the identification of a mutation, c.784G>A, in LMNA, resulting in a missense protein variant, p.Glu262Lys (E262K), that aggregates in nucleoplasm. "
10/01/2023 - "Furthermore, when compared to naturally-aged mice, a great proportion of differentially expressed circulating proteins in progeroid mice were specific to premature aging, highlighting secretome-associated differences between physiological and accelerated aging. "
01/01/2023 - "Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2."
12/01/2022 - "The protein Klotho (KL) was first discovered in KL-deficient mice, which developed a syndrome similar to premature aging in humans. "

07/01/2008 - "Recent studies suggest that FGF23 plays a certain role in premature aging process through altered P and vitamin D metabolism."
11/20/2022 - "Furthermore, dysregulation of vitamin D homeostasis has been associated with premature aging, driven by various cellular processes, including oxidative stress and cellular senescence. "
02/14/2018 - "Place of vitamin D in the prevention of premature aging and the development of age-associated diseases."
01/15/2018 - "[Place of vitamin D in the prevention of premature aging and the development of age-associated diseases]."
02/01/2017 - "Skin examination is highly informative in these patients and reveals features suggestive of premature aging and impaired vitamin D homeostasis."

01/01/2020 - "We previously reported that inducible whole-body Memo1 KO (cKO) mice displayed a syndrome of premature aging and disturbed mineral metabolism partially recapitulating the phenotype observed in Klotho or Fgf23-deficient mouse models. "
08/15/2015 - "In addition, in highly polluted areas, Hg and Cr contamination induced a process of premature aging of fishbone, altering its biochemical and mineral contents. "
03/01/2023 - "A wide variety of underlying pathophysiological processes have been identified, including premature aging, chronic wasting, and disturbances in vitamin D and mineral metabolism, which may impact bone fragility beyond established osteoporosis. "
10/01/2012 - "Mice lacking Klotho or fibroblast growth factor 23 (FGF23) exhibit a premature aging syndrome associated with abnormal mineral metabolism characterized by hyperphosphatemia, hypercalcemia, and hypervitaminosis D. "
03/01/2009 - "Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan. "

01/01/2018 - "Seminal studies on the klotho mouse, a mutant exhibiting a premature aging syndrome, have identified phosphate as a proaging factor in mammals. "
01/01/2021 - "In addition to disturbed phosphate homeostasis, mice lacking Klotho suffer from premature aging. "
01/01/2021 - "αKlotho-deficient mice have premature aging phenotypes and an imbalance of ion homeostasis including Ca2+ and phosphate. "
12/01/2013 - "When the phosphate level is increased in the blood by impaired urinary phosphate excretion, premature aging ensues. "
09/01/2010 - "Genetically reducing serum phosphate levels in klotho(-/-) mice by generating a NaPi2a and klotho double-knockout (NaPi2a(-/-)/klotho(-/-)) strain resulted in amelioration of premature aging-like features. "

07/01/2009 - "Premature aging in vitamin D receptor mutant mice."
04/01/2012 - "Here we analyzed premature aging, mineral homeostasis, carbohydrate metabolism, and fat metabolism in 9-month-old male wild-type (WT) mice, vitamin D receptor mutant mice (VDR(Δ/Δ)) with a nonfunctioning vitamin D receptor, and Fgf23⁻/⁻/VDR(Δ/Δ) compound mutant mice on both a standard rodent chow and a rescue diet enriched with calcium, phosphorus, and lactose. "
04/01/2011 - "Klotho(-/-)mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1α-hydroxylase, vitamin D receptor, or NaPi cotransporter). "
04/01/2011 - "Klotho⁻/⁻ mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1α-hydroxylase, vitamin D receptor, or NaPi cotransporter). "

07/01/2009 - "Hypervitaminosis vitamin D(3) has been recently implicated in premature aging through the regulation of 1alpha hydroxylase expression by klotho and fibroblast growth factor-23 (Fgf-23). "
04/01/2011 - "Klotho(-/-)mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1α-hydroxylase, vitamin D receptor, or NaPi cotransporter). "
04/01/2011 - "Klotho⁻/⁻ mice display premature aging and chronic kidney disease-associated mineral and bone disorder (CKD-MBD)-like phenotypes mediated by hyperphosphatemia and remediated by phosphate-lowering interventions (diets low in phosphate or vitamin D; knockouts of 1α-hydroxylase, vitamin D receptor, or NaPi cotransporter). "

01/05/2023 - "As oxidative stress is a significant cause of aging, we evaluated whether N-acetylcysteine (NAC) would inhibit Cd-induced premature aging and dysfunction in rat renal tubular epithelial cells. "
12/30/2009 - "Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1."
09/30/2020 - "We hypothesized that deficiency of the antioxidant protein glutathione (GSH) contributes to multiple defects representing premature aging in PWH, and that these defects could be improved by supplementing the GSH precursors glycine and N-acetylcysteine (GlyNAC). "

01/01/2022 - "The current study aimed at identifying the cause and pathogenesis of premature aging using biological markers. "
01/01/2021 - "Thus, we proposed a double-hit model for the development of premature aging outcomes in CP through shared biomarkers. "
01/01/2021 - "Can Be miR-126-3p a Biomarker of Premature Aging? "
01/01/2020 - "Our results suggest a complex interplay between biological markers and a potential key role of environmental factors, such as childhood trauma and psychological stress, in determining premature aging in patients. "
12/26/2019 - "Telomere length (TL) is a predictive biomarker of premature aging. "

01/01/2013 - "Therefore Zmpste24-deficient mice provide an ideal mouse model to study the impact of lamin A and (premature) aging on the aging-related decline of B lymphopoiesis. "
06/01/2012 - "The results of this study suggest that lamin A is up-regulated in OA chondrocytes, and that increased nuclear accumulation of lamin A in response to catabolic stress may account for the premature aging phenotype and apoptosis of OA chondrocytes."
02/01/2009 - "Recent studies have associated mutations in lamin A/C, a component of the nuclear lamina, with premature aging and severe bone loss. "
01/01/2023 - "These findings provide insight into how loss of the C-terminal region of lamin A may induce premature aging. "
12/31/2022 - "Structural basis for the interaction between unfarnesylated progerin and the Ig-like domain of lamin A/C in premature aging disorders."

09/01/2022 - "Consumption of some traditional herbs with antioxidant and anti-inflammatory properties such as Urtica dioica extract (Ud) and resistance training (RT) may be effective in controlling premature aging and memory impairment. "

11/10/2023 - "Given the emerging research on therapies for premature aging, this paradigm could create pathways for prevention of advanced CKD."
10/18/2021 - "Based on encouraging pre-clinical and clinical data, this review assesses the strong potential of MSC-based (cell and cell-free) therapies to counteract age-related consequences in both physiological and premature aging scenarios. "
01/01/2020 - "People with HIV on successful antiretroviral therapy show signs of premature aging and are reported to have higher rates of age-associated comorbidities. "
11/21/2018 - "The ability to detect premature aging could provide a window for preventive therapies against age-related diseases. "
01/01/2018 - "As such, induced Pluripotent Stem Cells (iPSCs) can provide models of progeroid and physiologically aged cells to gain insight into the pathogenesis of such conditions, to drive the development of new therapies for premature aging and to further explore the possibility of rejuvenating aged cells. "

01/01/1991 - "Light and electron microscope studies of the trabeculectomy specimen, which was obtained by en bloc resection of the trabecular meshwork and iridectomy specimen, revealed that the structures of the anterior-chamber angle were grossly normal aside from evidence of premature aging on the basis of abundant broad-banded collagen fibers in the trabecular lamellae."

06/18/1983 - "Thromboangiitis obliterans (Buerger's disease) was excluded by morphological studies of finger tips, temporal artery and dermis, which demonstrated arteriolar dysplasia and premature aging of the connective tissue. "

01/01/1991 - "Light and electron microscope studies of the trabeculectomy specimen, which was obtained by en bloc resection of the trabecular meshwork and iridectomy specimen, revealed that the structures of the anterior-chamber angle were grossly normal aside from evidence of premature aging on the basis of abundant broad-banded collagen fibers in the trabecular lamellae."