Dimethyl Fumarate

A fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS.

Also Known As:

2-butenedioic acid, (2E)-, dimethyl ester; BG 00012; BG 12 compound; BG-00012; BG-12 compound; BG00012; BG12 compound; Dimethylfumarate; FAG 201; FAG-201; FAG201; Fumaderm; Tecfidera; 00012, BG; 12 compound, BG; 201, FAG; Fumarate, Dimethyl; compound, BG 12; compound, BG12

Networked: 1006 relevant articles (102 outcomes, 178 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Fumarates: 813
        Dimethyl Fumarate: 1006

Experts

1.	Gold, Ralf: 41 articles (01/2022 - 10/2008)
2.	Fox, Robert J: 35 articles (01/2022 - 09/2012)
3.	Kappos, Ludwig: 24 articles (01/2022 - 10/2008)
4.	Phillips, J Theodore: 20 articles (06/2019 - 09/2012)
5.	Bar-Or, Amit: 19 articles (01/2022 - 09/2012)
6.	Giovannoni, Gavin: 15 articles (01/2018 - 09/2012)
7.	Arnold, Douglas L: 14 articles (01/2022 - 09/2012)
8.	Havrdova, Eva: 14 articles (01/2022 - 10/2008)
9.	Dawson, Katherine T: 14 articles (12/2017 - 10/2008)
10.	Mendoza, Jason P: 12 articles (07/2022 - 05/2018)

Related Diseases

1.	Multiple Sclerosis 01/01/2016 - "Dimethyl fumarate (DMF), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, has been proven effective for the systemic treatment of multiple sclerosis. " 01/01/2023 - "She received the medication dimethyl fumarate for the treatment of multiple sclerosis, and her CSA significantly improved to mild CSA after the treatment." 02/01/2015 - "Obtain a more precise estimate of the efficacy of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) in relapsing multiple sclerosis (MS) and examine the consistency of DMF's effects across patient subgroups stratified by baseline demographic and disease characteristics. " 08/10/2012 - "Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. " 06/01/2019 - "Delayed-release dimethyl fumarate (DMF) is an effective treatment for multiple sclerosis (MS). "
2.	Relapsing-Remitting Multiple Sclerosis 01/07/2019 - "Delayed-release dimethyl fumarate (DMF) has demonstrated efficacy and a favorable benefit-risk profile in phase 2 and 3 studies that enrolled predominantly white patients with relapsing-remitting multiple sclerosis (RRMS). " 01/01/2023 - "Dimethyl fumarate (DMF), a first-line drug for treating relapsing-remitting multiple sclerosis (RRMS), has been shown to be effective against various inflammatory diseases. " 12/01/2022 - "Dimethyl fumarate (DMF) is an effective treatment for relapsing remitting Multiple Sclerosis (MS) and its mechanisms of action encompass immunomodulatory and cytoprotective effects. " 12/01/2019 - "Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes." 02/01/2020 - "Dimethyl-fumarate (DMF) was effective and safe in relapsing-remitting multiple sclerosis (MS) in randomized clinical trials. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 08/01/2013 - "Dimethyl fumarate (DMF) has been used as fungicide, but oral DMF activates anti-inflammatory and anti-oxidative pathways that are beneficial in the treatment of psoriasis. " 01/01/2007 - "Dimethyl fumarate (DMF) is used successfully to treat psoriasis. " 06/01/2020 - "Background: Dimethylfumarate (DMF) is an effective treatment for psoriasis, which may cause side effects in a considerable group of patients. " 10/01/2019 - "Dimethyl fumarate is effective and safe in the systemic treatment of adults with severe psoriasis (physician global assessment)." 01/01/2021 - "On October 29th, there was a Session on systemic treatment in which Professors Ulrich Mrowietz and Mar Llamas-Velasco presented the latest research on the efficacy of dimethyl fumarate (DMF) treatment for moderate-to-severe plaque psoriasis (BRIDGE and DIMESKIN 1 studies, respectively). "
4.	Inflammation (Inflammations) 12/01/2020 - "The present study aimed to explore the effects of dimethyl fumarate (DMF) on inflammation and oxidative stress in the intervertebral disc. " 01/01/2023 - "Experimental Investigations of Monomethyl and Dimethyl Fumarate in an Astrocyte-Microglia Co-Culture Model of Inflammation." 12/07/2022 - "The glycolysis-targeting drug dimethyl fumarate (DMF) showed both bacteriostatic and anti-inflammatory effects by hindering the proliferation of intracellular MRSA and dampening excessive intraarticular inflammation. " 12/01/2021 - "Switch off inflammation in spleen cells with CD40-targeted PLGA nanoparticles containing dimethyl fumarate." 09/01/2021 - "Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB signal pathway."
5.	Neoplasms (Cancer) 05/01/2022 - "Dimethyl fumarate (DMF) has several effects in cancer cells, including cell signaling, proliferation and cell death. " 04/01/2021 - "Detailed description of patients who developed cancer among a prospective cohort of Spanish MS patients on dimethyl fumarate (DMF) treatment. " 01/01/2021 - "Several known ferroptosis activators and dimethyl fumarate (DMF), a cell-permeable mitochondrial metabolite derivative, led to selective synthetic lethality in HIF-2α-expressing tumor enteroids. " 02/06/2018 - "Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells." 01/01/2017 - "Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications."

Related Drugs and Biologics

1.	Fumarates
2.	teriflunomide
3.	Inflammasomes
4.	Fingolimod Hydrochloride (FTY720)
5.	Antioxidants
6.	Rituximab (Mabthera)
7.	Cladribine
8.	Proteins (Proteins, Gene)
9.	laquinimod
10.	Dimethyl Fumarate

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Phototherapy (Light Therapy)
4.	Hypnosis (Mesmerism)
5.	Immunomodulation