Efficacy of dimethyl fumarate treatment for moderate-to-severe plaque psoriasis: presentation extracts from the 29th EADV virtual congress, 29-31 October 2020.

Abstract

Background: The 29th EADV Virtual Congress took place between the 29th-31st of October 2020. On October 29th, there was a Session on systemic treatment in which Professors Ulrich Mrowietz and Mar Llamas-Velasco presented the latest research on the efficacy of dimethyl fumarate (DMF) treatment for moderate-to-severe plaque psoriasis (BRIDGE and DIMESKIN 1 studies, respectively). The accepted DMF abstract from Professor Matthias Augustin, on the SKILL study, is also presented here. Results: Data from either prospective interventional (BRIDGE) or non-interventional (DIMESKIN 1, SKILL) studies among patients with moderate-to-severe psoriasis showed that DMF provides a positive efficacy profile in all four body regions included in the Psoriasis Area and Severity Index assessment (head and neck, trunk, upper and lower extremities) and a particularly interesting profile (strong efficacy) in the head and neck region. These findings may be of special interest to patients with scalp psoriasis who have been using topical therapies for a long time. Patient-reported outcomes (quality of life, pruritus) also improved during the 24 weeks of DMF treatment. The safety profile of DMF was similar to the previously described with fumaric acid esters. Conclusions: In summary, these results confirm the favorable efficacy and safety profile of DMF in long-term treatment.

• Authors: Ulrich Mrowietz, Peter Van De Kerkhof, Andreu Schoenenberger, Anna Ryzhkova, Ignasi Pau-Charles, Mar Llamas-Velasco, Esteban Daudén, José Manuel Carrascosa, Pablo De La Cueva, Laura Salgado-Boquete, Meritxell Guilà, Francisco Javier Fernández-Soriano, Matthias Augustin, Christine Loew-Juettner, Astrid Kirsch, Sebastian Diemert, Ina Hadshiew
• Journal: Expert review of clinical immunology (Expert Rev Clin Immunol) Vol. 17 Issue sup2 Pg. 1-11 (05 2021) ISSN: 1744-8409 [Electronic] England
• PMID: 33899642 (Publication Type: Journal Article)