levomefolate calcium

an ingredient in Contraceptives, Oral, Combined

Also Known As:

N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid calcium salt; metafolin; safyral

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - levomefolate calcium: 7
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - levomefolate calcium: 7

Experts

1.	Jiang, Hong: 1 article (11/2020)
2.	Liu, Zhiping: 1 article (11/2020)
3.	Townsend, Justin H: 1 article (11/2020)
4.	Wang, Jianhua: 1 article (11/2020)
5.	Macaluso, Matthew: 1 article (09/2020)
6.	Vu, Thien: 1 article (09/2020)
7.	Zackula, Rosalee: 1 article (09/2020)
8.	Blagonravova, A S: 1 article (01/2020)
9.	Mazo, G E: 1 article (01/2020)
10.	Zhilyaeva, T V: 1 article (01/2020)

Related Diseases

1.	Congenital Abnormalities (Deformity) 07/01/2013 - "Analysis of the recent literature reposts suggests that metafolin could be an effective and safe alternative to folic acid supplementation and could effectively prevent complications in pregnancy and series birth defects in fetuses and newborns."
2.	Neural Tube Defects (Exencephaly) 11/01/2011 - "The objective of the study was to estimate the potential reduction of neural tube defects (NTDs) through the use of Metafolin-fortified oral contraceptives (OCs) in the United States. " 11/01/2011 - "Potential reduction in neural tube defects associated with use of Metafolin-fortified oral contraceptives in the United States." 01/01/2012 - "In addition, the 24-day regimen with 20 µg EE/3 mg drospirenone/levomefolate calcium assure significant increases in red blood cell and plasma folate levels reaching values indicated to be protective in reducing the risk of neural tube defects. " 10/01/2011 - "A new oral contraceptive containing drospirenone and ethinyl estradiol plus levomefolate calcium was formulated to decrease the risk of neural tube defects in pregnancies conceived while taking or shortly after discontinuing this pill. "
3.	Schizophrenia (Dementia Praecox) 01/01/2020 - "Using a battery of cognitive tests, the authors evaluated the dynamics of cognitive functions in 3 groups of patients with schizophrenia who received folic acid (n=25), metafolin (n=25) during 4 weeks and in the control group (n=25). " 09/01/2020 - "Genetic polymorphisms of MTHFR have potential clinical implications, particularly in treating mental disorders, where a biologically active form of metafolin is FDA approved in the treatment of major depressive disorder and schizophrenia. "
4.	Diabetic Retinopathy (Retinopathy, Diabetic) 11/01/2020 - "To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients. "
5.	Major Depressive Disorder (Major Depressive Disorders) 09/01/2020 - "Genetic polymorphisms of MTHFR have potential clinical implications, particularly in treating mental disorders, where a biologically active form of metafolin is FDA approved in the treatment of major depressive disorder and schizophrenia. "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Oral Contraceptives
3.	drospirenone
4.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
5.	Salts
6.	Ethinyl Estradiol (Estinyl)
7.	Calcium
8.	Acids
9.	mecobalamin (methylcobalamin)