human CGA protein

11/08/1997 - "Immunohistochemistry indicated the tumor cells to be frequently positively stained for HCG alpha and FSH. "
07/15/1992 - "Significant serum elevations of free hCG alpha subunit (as high as 3000 pg/ml) were found in approximately 96% of cancer patients, normal individuals, and disease controls. "
12/01/1989 - "The inverse correlation was found between the value of D and the frequency of hCG alpha in the tumor or in the neoplastic cells (P less than 0.05). "
01/01/1989 - "Serum HCG-alpha and -beta subunits were elevated in 41 and 30% respectively, all except 3 having a verified malignant tumor. "
08/23/1988 - "However, comparison of hCG-alpha and HeLa-alpha demonstrated that the tumor-associated subunit was not identical with its normal counterpart. "

10/01/1979 - "The present results suggest that measurements of the serum free hCG-alpha may be a useful parameter to follow the clinical course and to evaluate the efficacy of treatments of trophoblastic diseases."
10/01/1979 - "The changes in the serum level of free hCG-alpha as well as that of hCG parelled the clinical course of the patients examined in this study. "
09/15/1977 - "In one patient responding to streptozocin, changes in hCG-alpha correlated with the clinical course. "

02/15/1985 - "After surgery and initial treatment, 126 patients with nonseminomatous germ cell tumors of the testis were followed by estimation of serum human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and pregnancy-specific beta-1-glycoprotein (SP-1). "
01/01/1984 - "Human chorionic gonadotrophin(hCG)-producing cells in the human placenta and in testicular germ cell tumors have been investigated by ultrastructural immunohistochemistry using labeled Fab'fragments of anti-hCG-alpha and anti-hCG-beta. "
01/01/1990 - "hCG alpha was expressed preferentially in the endocrine tumors of the thymus and non-germ-cell tumor, with rare positivity for beta-subunits of glycoprotein hormones. "
03/01/1985 - "Included in the review were an additional seven patients with undifferentiated tumors with a pathologic appearance compatible with that of a germ cell tumor and elevated levels of serum biomarkers (beta subunit of human chorionic gonadotropin [beta-HCG] +/- alpha-fetoprotein [AFP]. "
09/01/1981 - "Pregnancy Specific beta 1 Glycoprotein (PS beta 1G), human choriogonadotropin (hCG), alpha foeto protein (AFP) and Carcino Embryonic Antigen (CEA) were assayed in 58 patients with active germ cell tumors and 20 patients in complete clinical and radiological remission. "

11/01/1980 - "All patients who were treated with chemotherapy for malignant gestational trophoblastic neoplasms at the Southeastern Regional Trophoblastic Disease Center and who experienced remission during the period January 1, 1978, through December 31, 1979, were studied in an attempt to determine if the application of an assay for the alpha subunit of human chorionic gonadotropin (hCG-alpha) could predict those patients who would have recurrences. "

01/01/1987 - "In the present study, we compared the effects of cAMP on HCG alpha-subunit expression in human choriocarcinoma cells and in nontrophoblastic mouse L-cells stably transfected with the HCG alpha-subunit gene. "
06/20/1991 - "[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]."
01/01/1991 - "RA in physiologic concentrations stimulates hCG and hCG-alpha secretion by three choriocarcinoma cell lines in vitro. "
01/01/1991 - "In two fatal choriocarcinoma patients, large hCG and large hCG alpha were found in the urine samples collected within one month prior to death. "
03/01/1985 - "By contrast, choriocarcinoma, which is devoid of placental villous pattern but in which the cyto- and syncytiotrophoblast-like components are distinguishable, expresses hCG alpha and beta in the syncytial-like areas but little, if any, hPL. "