Abstract | OBJECTIVES: PATIENTS AND METHODS: Two cases of bronchic NET were observed, both in women, and 4 cases of thymic NET, all in men, giving a prevalence of 7.3%. These NET were often asymptomatic. A metastatic diffusion was observed in 3 cases. Elevated plasma levels of glycoprotein hormone alpha subunit (SU) and FSH were observed in 3 and 1 cases respectively. Immunohistochemistry indicated the tumor cells to be frequently positively stained for HCG alpha and FSH. DISCUSSION: We conclude that all patients with MEN 1 should undergo screening for thoracic NET, especially in high risk familial subgroups and in case of elevated plasma alpha SU or FSH.
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Authors | A Murat, M F Heymann, S Bernat, B Dupas, A Y Delajartre, A Calender, P Despins, J L Michaud, S Giraud, M F Le Bodic, B Charbonnel |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 26
Issue 34
Pg. 1616-21
(Nov 08 1997)
ISSN: 0755-4982 [Print] France |
Vernacular Title | Tumeurs neuro-endocrines thymiques et bronchiques au cours des néoplasies endocrines multiples de type 1. GENEM1. |
PMID | 9452725
(Publication Type: Case Reports, English Abstract, Journal Article)
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Topics |
- Adult
- Bronchial Neoplasms
(diagnosis, immunology, physiopathology)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
(immunology, physiopathology)
- Prospective Studies
- Retrospective Studies
- Thymus Neoplasms
(diagnosis, immunology, physiopathology)
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