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lapiferin

from Ferula vesceritensis, induces apoptosis pathway in MCF-7 breast cancer cells; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - lapiferin: 3

Experts

1.	Liu, Lin: 1 article (07/2021)
2.	Peng, Cheng: 1 article (07/2021)
3.	Ruan, Yan: 1 article (07/2021)
4.	Zhang, Qian: 1 article (07/2021)
5.	Feng, Xiao: 1 article (01/2020)
6.	Gao, Xuejin: 1 article (01/2020)
7.	Lai, Yanping: 1 article (01/2020)
8.	Liu, Wen: 1 article (01/2020)
9.	Pei, Lishu: 1 article (01/2020)
10.	Zhao, Zhongquan: 1 article (01/2020)

Related Diseases

1.	Pneumonia (Pneumonitis) 01/01/2020 - "The present study evaluated the protective roles of a natural compound, lapiferin, in H1N1 virus-induced pulmonary inflammation in mice and in cultured human bronchial epithelial cells. " 01/01/2020 - "Lapiferin protects against H1N1 virus-induced pulmonary inflammation by negatively regulating NF-kB signaling."
2.	Neoplasms (Cancer) 02/01/2010 - "vesceritensis as a new natural source of lapiferin and its first X-ray analysis, and the promising specific anti-cancer activity against human breast cancer of lapiferin and accordingly F. " 02/01/2010 - "We also report for the first time the specific anti-cancer activity of lapiferin against human breast cancer cells (MCF-7), which is due to apoptosis and not necrosis. " 07/01/2021 - "Furthermore, following treatment with lapiferin, the critical cell cycle regulators cell division cycle 25C and cyclin B1 and tumor cell proliferation markers proliferating cell nuclear antigen and Ki67 were markedly decreased. "
3.	Virus Diseases (Viral Diseases) 01/01/2020 - "These results suggested that lapiferin was a potent natural compound that served as a therapeutic agent for virus infection in the lung."
4.	Necrosis 02/01/2010 - "We also report for the first time the specific anti-cancer activity of lapiferin against human breast cancer cells (MCF-7), which is due to apoptosis and not necrosis. "
5.	Infections 01/01/2020 - "Initially, Balb/C mice were grouped as Control, H1N1 infection (intranasally infected with 500 plaque-forming units of H1N1 virus), lapiferin (10 mg/kg), and H1N1+lapiferin (n=10/group). "

Related Drugs and Biologics

1.	Cyclin B1
2.	Caspases
3.	Proliferating Cell Nuclear Antigen (PCNA)
4.	NF-kappa B (NF-kB)
5.	Histones (Histone)