|1.||Rui, Bai: 1 article (12/2015)|
|2.||Xiao-Zhen, Cui: 1 article (12/2015)|
|3.||Shan, Li: 1 article (12/2015)|
|4.||Ming-Xue, Zheng: 1 article (12/2015)|
|5.||Wen-Long, Zhao: 1 article (12/2015)|
|6.||Zhi-Yong, Xu: 1 article (12/2015)|
|7.||Sha-Sha, Yang: 1 article (12/2015)|
|8.||Qiang-Hua, Lv: 1 article (12/2015)|
|9.||Yan, Zhang: 1 article (12/2015)|
|10.||Huan-Cheng, Xu: 1 article (12/2015)|
|2.||Spinal Cord Injuries (Spinal Cord Injury)
03/01/2005 - "The aim of this study was to evaluate the neuroprotective effect of the caspase-9 inhibitor, z-LEHD-fmk, in a rat model of spinal cord trauma. "
03/01/2005 - "Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury."
07/01/2013 - "We investigated the individual and combined effects of magnesium sulphate, which is an N-Methyl-D aspartate receptor antagonist (NMDA), and z-LEHD-FMK, which is a caspase 9 inhibitor, on the genesis of secondary injury in a rat spinal cord injury model. "
11/01/2002 - "Knock-out studies in mice show that thymocytes are Type I and liver cells are Type II. We have previously shown that primary human hepatocytes and HCT116 human colon carcinoma cells behave like Type II cells because TRAIL-induced apoptosis can be blocked by the caspase 9 inhibitor, Z-LEHD-FMK. "
04/01/2005 - "Selective inhibitors of caspase-2 (Z-VDVAD-FMK), caspase-9 (Z-LEHD-FMK), and caspase-3 (Z-DEVD-FMK) protected both leukemia and carcinoma cells from LfcinB-induced apoptosis. "
|4.||Breast Neoplasms (Breast Cancer)
12/01/2015 - "tenella infection rates, DNA injury rates, and apoptosis rates in groups treated with and without the caspase-9 inhibitor Z-LEHD-FMK. "
09/02/2004 - "Selective blockage of caspase-9 activities by Z-LEHD-FMK completely attenuated DAC-induced enhancement of apoptosis mediated by Ad-p53 infection, and ectopic overexpression of procaspase-9 sensitized cells to Ad-p53-induced apoptosis in p53-null cells. "
10/10/2007 - "To determine the caspase activation pathways involved in EAV-induced apoptosis, target cells were treated with peptide inhibitors of apoptosis Z-VAD-FMK (pan-caspase inhibitor), Z-IETD-FMK (caspase-8-specific inhibitor) or Z-LEHD-FMK (caspase-9-specific inhibitor) 4 h prior to infection with the EAV T1329 Canadian isolate. "
10/01/2015 - "Interestingly, caspase-2 and -8 were not cleaved or activated during the infection, whilst a selective inhibitor of caspase-9, Z-LEHD-FMK, blocked the cleavage of caspase-3 and -7, indicating that only the mitochondria-mediated intrinsic apoptotic pathway was activated in EV71-infected astrocytes. "
|2.||Caspase 3 (Caspase-3)
|3.||benzyloxycarbonyl- isoleucyl- glutamyl- threonyl- aspartic acid fluoromethyl ketone
|4.||benzoylcarbonyl- aspartyl- glutamyl- valyl- aspartyl- fluoromethyl ketone
|5.||Caspase 8 (Caspase-8)
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|9.||benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone