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Caspase 9

A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
Also Known As:
Apoptotic Protease Activating Factor 3; Caspase-9; ICE-LAP6 Protein; ICE-Like Apoptotic Protease 6; Pro-Caspase-9; Procaspase-9; ICE LAP6 Protein; ICE Like Apoptotic Protease 6; Pro Caspase 9; Procaspase 9
Networked: 2325 relevant articles (48 outcomes, 186 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Delivoria-Papadopoulos, Maria: 13 articles (08/2012 - 07/2004)
2. Mishra, Om P: 12 articles (08/2010 - 07/2004)
3. Wang, Ying: 10 articles (06/2022 - 07/2010)
4. Li, Ming: 9 articles (10/2022 - 03/2010)
5. Wang, Xin: 9 articles (07/2020 - 09/2009)
6. Kim, Sung-Hoon: 9 articles (03/2019 - 10/2004)
7. Dent, Paul: 9 articles (01/2019 - 05/2002)
8. Chung, Jing-Gung: 9 articles (10/2013 - 01/2009)
9. Chen, Jun: 8 articles (01/2022 - 05/2002)
10. Lee, Shin-Da: 8 articles (01/2022 - 08/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Ischemia
3. Infarction (Infarctions)
4. Hypoxia (Hypoxemia)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Caspase 3 (Caspase-3)
2. Cytochromes c (Cytochrome c)
3. Proteins (Proteins, Gene)
4. Caspase 8 (Caspase-8)
5. Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6. Caspases
7. Reactive Oxygen Species (Oxygen Radicals)
8. Messenger RNA (mRNA)
9. oxidized low density lipoprotein
10. Caspase 9

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Heterologous Transplantation (Xenotransplantation)
4. Intravenous Administration
5. Drug Therapy (Chemotherapy)