HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

isogranulatimide

G2 checkpoint inhibitor; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - isogranulatimide: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - isogranulatimide: 4

Experts

1.	Delfourne, Evelyne: 2 articles (04/2015 - 09/2014)
2.	Lavrard, Hubert: 2 articles (04/2015 - 09/2014)
3.	Rodriguez, Frédéric: 2 articles (04/2015 - 09/2014)
4.	Kiss, Robert: 1 article (04/2015)
5.	Mathieu, Véronique: 1 article (04/2015)
6.	Salvetti, Béatrice: 1 article (04/2015)
7.	Anizon, Fabrice: 1 article (09/2007)
8.	Bailly, Christian: 1 article (09/2007)
9.	Golsteyn, Roy M: 1 article (09/2007)
10.	Hickman, John: 1 article (09/2007)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2004 - "The mechanism by which isogranulatimide inhibits Chk1 and its favorable kinase selectivity profile make it a promising candidate for modulating checkpoint responses in tumors for therapeutic benefit." 09/01/2014 - "The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a promising target for cancer treatment. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2007 - "The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carcinoma, A549 non-small cell lung carcinoma, and HT29 colon carcinoma) are described. " 04/01/2015 - "Two of the compounds synthesized exhibited more potent in vitro antiproliferative activity (single-digit micromolar concentration range), by at least one log of magnitude, than the natural product isogranulatimide when evaluated in six human tumor cell lines: non-small-cell lung cancer (A549), colon cancer (LoVo), breast cancer (MCF7), oligodendroglioma (Hs683), glioblastoma (U373), and melanoma (SKMEL28). "
3.	Oligodendroglioma 04/01/2015 - "Two of the compounds synthesized exhibited more potent in vitro antiproliferative activity (single-digit micromolar concentration range), by at least one log of magnitude, than the natural product isogranulatimide when evaluated in six human tumor cell lines: non-small-cell lung cancer (A549), colon cancer (LoVo), breast cancer (MCF7), oligodendroglioma (Hs683), glioblastoma (U373), and melanoma (SKMEL28). "
4.	Melanoma (Melanoma, Malignant) 04/01/2015 - "Two of the compounds synthesized exhibited more potent in vitro antiproliferative activity (single-digit micromolar concentration range), by at least one log of magnitude, than the natural product isogranulatimide when evaluated in six human tumor cell lines: non-small-cell lung cancer (A549), colon cancer (LoVo), breast cancer (MCF7), oligodendroglioma (Hs683), glioblastoma (U373), and melanoma (SKMEL28). "
5.	Leukemia L1210 09/01/2007 - "The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carcinoma, A549 non-small cell lung carcinoma, and HT29 colon carcinoma) are described. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Alkaloids
3.	Checkpoint Kinase 1
4.	granulatimide