Abstract |
The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a promising target for cancer treatment. A molecular docking study allowing the design of new potential Chk1 inhibitors based on the natural products skeleton and the synthetic work to an amino-target platform to prepare them are described.
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Authors | Hubert Lavrard, Frédéric Rodriguez, Evelyne Delfourne |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 22
Issue 17
Pg. 4961-7
(Sep 01 2014)
ISSN: 1464-3391 [Electronic] England |
PMID | 25047935
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Alkaloids
- Imidazoles
- Indoles
- Protein Kinase Inhibitors
- granulatimide
- isogranulatimide
- Protein Kinases
- Checkpoint Kinase 1
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Topics |
- Alkaloids
(chemical synthesis, chemistry, pharmacology)
- Checkpoint Kinase 1
- Dose-Response Relationship, Drug
- Drug Design
- Imidazoles
(chemical synthesis, chemistry, pharmacology)
- Indoles
(chemical synthesis, chemistry, pharmacology)
- Models, Molecular
- Molecular Structure
- Protein Kinase Inhibitors
(chemical synthesis, chemistry, pharmacology)
- Protein Kinases
(metabolism)
- Structure-Activity Relationship
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