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Oligodendroglioma

A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Also Known As:
Anaplastic Oligodendroglioma; Mixed Oligodendroglioma-Astrocytoma; Mixed Oligodendroglioma-Ependymoma; Oligodendroglioma, Adult; Oligodendroglioma, Childhood; Oligodendroglioma, Well-Differentiated; Well-Differentiated Oligodendroglioma; Adult Oligodendroglioma; Adult Oligodendrogliomas; Anaplastic Oligodendrogliomas; Childhood Oligodendroglioma; Childhood Oligodendrogliomas; Mixed Oligodendroglioma Astrocytoma; Mixed Oligodendroglioma Ependymoma; Mixed Oligodendroglioma-Astrocytomas; Mixed Oligodendroglioma-Ependymomas; Oligodendroblastomas; Oligodendroglioma, Anaplastic; Oligodendroglioma, Well Differentiated; Oligodendroglioma-Astrocytoma, Mixed; Oligodendroglioma-Astrocytomas, Mixed; Oligodendroglioma-Ependymoma, Mixed; Oligodendroglioma-Ependymomas, Mixed; Oligodendrogliomas; Oligodendrogliomas, Adult; Oligodendrogliomas, Anaplastic; Oligodendrogliomas, Childhood; Oligodendrogliomas, Well-Differentiated; Well Differentiated Oligodendroglioma; Well-Differentiated Oligodendrogliomas; Oligodendroblastoma
Networked: 1488 relevant articles (59 outcomes, 191 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Astrocytoma (Pilocytic Astrocytoma)
2. Neoplasms (Cancer)
3. Glioma (Gliomas)
4. Glioblastoma (Glioblastoma Multiforme)
5. Oligodendroglioma

Experts

1. van den Bent, Martin J: 19 articles (01/2020 - 03/2003)
2. von Deimling, Andreas: 17 articles (12/2022 - 10/2004)
3. Weller, Michael: 17 articles (01/2022 - 10/2002)
4. Cairncross, J Gregory: 17 articles (01/2021 - 01/2002)
5. Sanson, Marc: 15 articles (01/2020 - 05/2004)
6. Kros, Johan M: 12 articles (01/2020 - 03/2002)
7. Hartmann, Christian: 11 articles (01/2021 - 10/2004)
8. Louis, David N: 11 articles (10/2017 - 01/2002)
9. Mason, Warren P: 10 articles (05/2022 - 02/2005)
10. Giannini, Caterina: 10 articles (01/2021 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Oligodendroglioma:
1. Temozolomide (Temodar)FDA LinkGeneric
2. Vincristine (Oncovin)FDA LinkGeneric
3. Procarbazine (Matulane)FDA Link
4. ranimustineIBA
5. Lomustine (CCNU)FDA Link
06/01/2005 - "Twelve (92%) patients treated with CCNU had MGMT-negative lesions and their median survival was 73 months; 1 patient had an MGMT-positive oligodendroglioma and is alive at 28 months. "
11/01/2012 - "Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU."
06/01/2005 - "We evaluated the immunohistochemical MGMT expression in 28 consecutive oligodendroglial tumors (21 oligodendrogliomas, 5 mixed oligoastrocytomas, and 2 glioblastomas with prominent oligodendroglial features; 13 treated with CCNU) and compared it with that of 13 glioblastomas. "
06/13/2022 - "NOA-18 aims at improving qualified overall survival (qOS) for adult patients with CNS WHO grade 2 and 3 oligodendrogliomas by randomizing between standard chemoradiation with up to six six-weekly cycles with PCV and six six-weekly cycles with lomustine and temozolomide (CETEG) (n = 182 patients per group accrued over 4 years) thereby delaying radiotherapy and adding the chemoradiotherapy concept at progression after initial radiation-free chemotherapy, allowing for effective salvage treatment and delaying potentially deleterious side effects. "
06/01/2023 - "We describe a 43-year-old male patient with a history of grade two left frontal oligodendroglioma, which was treated with two partial resections, radiation treatment and procarbazine/lomustine, who presented with left upper extremity pain and developed a blistering rash in a dermatomal pattern in the left proximal upper extremity two weeks after the initial symptoms. "
6. Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
7. Complementary DNA (cDNA)IBA
8. Carmustine (FIVB)FDA Link
9. Irinotecan (Camptosar)FDA LinkGeneric
10. Alkylating AgentsIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Therapeutics
4. Adjuvant Chemotherapy
5. Combination Drug Therapy (Combination Chemotherapy)