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CPH 82

semisynthetic derivative from Podophyllum emodi; consists of two lignan glycosides

Also Known As:

CPH-82

Networked: 8 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - CPH 82: 8
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        CPH 82: 8

Experts

1.	Lerndal, T: 2 articles (03/2000 - 01/2000)
2.	Svensson, B: 1 article (03/2000)
3.	Axelson, M: 1 article (01/2000)
4.	Carlström, K: 1 article (01/2000)
5.	Chatterton, R T: 1 article (01/2000)
6.	Gudmundsdóttir, E S: 1 article (01/2000)
7.	Hedin, P J: 1 article (01/2000)
8.	Jónsson, H: 1 article (01/2000)
9.	Jönsson, L: 1 article (01/2000)
10.	Lien, J: 1 article (01/2000)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2000 - "Endocrine effects of the podophyllotoxine derivative drug CPH 82 (Reumacon) in patients with rheumatoid arthritis." 10/01/1989 - "A drug composed of two semisynthetic podophylline derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. " 04/01/1989 - "Podophyllum derivatives (CPH 82) compared with placebo in the treatment of rheumatoid arthritis." 03/01/2000 - "The objectives of this study were to evaluate the therapeutic efficacy of CPH 82 in comparison with methotrexate (MTX) in adult patients with early, active rheumatoid arthritis (RA) and to compare the tolerance and safety profiles of the two drugs. " 01/01/1998 - "The onset of action rate of CPH-82 (Reumacon), was compared with that of auranofin (AUR; Ridaura) in a 36-week randomised, double-blind, multicentre study of 60 patients with rheumatoid arthritis (RA). "
2.	Pain (Aches) 01/01/1998 - "As compared with respective baseline values, the CPH-82 group manifested significant improvement in grip strength, Ritchie's articular index (RAI), pain ratings, and HAQ (health assessment questionnaire) scores after 8, 12, 24, and 36 weeks of treatment, with the exception of the 24-week HAQ score. "
3.	Arthritis (Polyarthritis) 01/01/2000 - "CPH 82 (Reumacon) in refractory inflammatory arthritis." 01/01/1993 - "A patient suffering from seronegative polyarthritis was treated with CPH-82 (Reumacon). " 01/01/2000 - "In this retrospective analysis of the DMARD CPH 82 in 44 Icelandic patients with severe refractory arthritis, clinical tolerance was good and serious side effects absent, although the majority were using the drug in combination with other DMARDS. "
4.	Abdominal Pain (Pain, Abdominal) 04/01/1989 - "Some patients treated with CPH 82 reported gastrointestinal discomfort (diarrhoea and abdominal pain)."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	ametantrone (HAQ)
3.	Lignans
4.	Glycosides
5.	Auranofin (Ridaura)
6.	Antirheumatic Agents (DMARD)
7.	Glucocorticoids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)