tryptanthrine

06/01/2021 - "According to the results from in vivo experiment, tryptanthrin was effective in inhibiting tumor growth, and it showed favorable safety without inducing the fluctuations of body mass and organ coefficient (p > 0.05). "
10/24/2021 - "In this study, a series of tryptanthrin derivatives were synthesized to generate potent anti-tumor agents against HCC. "
10/31/2023 - "Significant anti-tumor effects were observed in all 48-hpf (hours post-fertilization) zebrafish treated with tryptanthrin (P<0.05). "
10/31/2023 - "Tryptanthrin inhibits tumor angiogenesis via Notch/Dll4 signaling pathway in zebrafish."
12/01/2022 - "Some of them have been shown to have higher cytotoxicity against tumor and microbial cells than tryptanthrin and mostotrin. "

01/01/2020 - "Tryptanthrin promotes keratinocyte and fibroblast responses in vitro after infection with Trichophyton benhamiae DSM6916."
11/01/2019 - "Collectively, the study establishes the first report on the anti-biofilm property of tryptanthrin by targeting LuxO, which could serve as a potential antivirulent therapy to combat V. cholerae infections."
01/01/2020 - "The results specify that tryptanthrin possesses antiviral potential against HCoV-NL63 infection."

08/10/2022 - "Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis."
01/01/2020 - "The present study investigates the efficacy of tryptanthrin, a bioactive compound in indigo naturalis, against non-melanoma skin cancer (NMSC) and the signalling events involved. "
08/10/2022 - "We demonstrate that tryptanthrin (Tpn), an indole quinazoline alkaloid, which we isolated and characterized from Wrightia tinctoria, exhibits remarkable anti-tumor activity towards human melanoma through the down-regulation of MITF-M. "

01/01/2020 - "Pre-clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer."
01/01/2020 - "The present study investigates the efficacy of tryptanthrin, a bioactive compound in indigo naturalis, against non-melanoma skin cancer (NMSC) and the signalling events involved. "

01/01/2021 - "Our findings indicate that tryptanthrin may be useful for regulating TLR3-mediated vascular inflammation."
01/01/2017 - "It was found tryptanthrin protected BV2 microglia cells against LPS-induced inflammation and inhibited the induction of M1 phenotype microglia under inflammatory conditions. "
05/01/2006 - "The effects of a supercritical CO2 (SFE) extract, a dichloromethane (DCM) extract from Isatis tinctoria leaf and the alkaloidal constituent tryptanthrin were studied in acute and subchronic experimental models of inflammation. "
01/01/2023 - "Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-κB/MAPK/Nrf2 pathways."
01/01/2011 - "Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. "