|1.||Bakker, Stephan J L: 1 article (01/2015)|
|2.||Landman, Gijs W D: 1 article (01/2015)|
|3.||van Dijk, Peter R: 1 article (01/2015)|
|4.||Bilo, Henk J G: 1 article (01/2015)|
|5.||Struck, Joachim: 1 article (01/2015)|
|6.||van Essen, Larissa: 1 article (01/2015)|
|7.||Kleefstra, Nanne: 1 article (01/2015)|
|8.||Groenier, Klaas H: 1 article (01/2015)|
|9.||Rougeot, C: 1 article (01/2003)|
|10.||Delacourte, A: 1 article (01/2003)|
|1.||Thyroid Neoplasms (Thyroid Cancer)
01/01/1986 - "Nonsomatostatin secretory peptide(s) derived from prosomatostatin's amino terminus in a rat medullary thyroid carcinoma cell line."
05/10/1983 - "In these studies, we present the complete sequence of rat pre-prosomatostatin, deduced from the nucleotide sequence of cDNAs derived from a somatostatin-rich medullary thyroid carcinoma. "
03/01/1987 - "The fact that the products of prosomatostatin processing in these cells are similar to those in normal tissues indicates that the TT medullary thyroid carcinoma cell line constitutes a useful model for human somatostatin gene expression."
05/10/1983 - "Cell-free translations of medullary thyroid carcinoma mRNA with dog pancreas microsomal membranes were performed to identify the cleavage point of the leader region from prosomatostatin. "
08/01/1990 - "Thirty-three cases of histologically proven calcitonin-positive medullary thyroid carcinoma were studied immunocytochemically for the occurrence of prosomatostatin-related peptides. "
01/01/1995 - "We have investigated the endogenous and heterologous synthesis and processing of rat prosomatostatin in 1027B2 rat islet somatostatinoma cells and in constitutive (COS-7, PC-12) and regulated (AtT-20, GH3/GH4C1) secretory cells. "
03/01/1992 - "These studies suggest that the synthesis of somatostatin in ampullary somatostatinomas occurs through the normal pathway from the precursor prosomatostatin."
11/01/1983 - "2) Both tumor and plasma S-14 LI and S-28 LI were heterogeneous and comprised species corresponding not only to S-14 but also S-28, S-28(1-12), prosomatostatin, and other higher mol wt forms of S-28.(ABSTRACT TRUNCATED AT 400 WORDS)"
08/01/1990 - "Positive cells, identified with a panel of antisera raised against four different regions of the prosomatostatin molecule, were found in 100% of the tumors. "
10/01/1985 - "This result demonstrates that the tumor has the ability to constitutively express the prosomatostatin gene and to process the primary translation product to somatostatin-14."
08/01/1990 - "The results (1) indicate that somatostatin production is a universal concomitant of thyroid medullary carcinoma, (2) suggest that these cells are likely to produce a somatostatin precursor molecule similar to mammalian prosomatostatin, and (3) imply that somatostatin-reactive cells may have as yet unknown roles in these tumors, possibly in the realm of paracrine and autocrine regulation of cell growth."
08/08/1997 - "Somatostatin-14, somatostatin-28, and prosomatostatin[1-10] are independently and efficiently processed from prosomatostatin in the constitutive secretory pathway in islet somatostatin tumor cells (1027B2)."
10/01/1991 - "These results suggest that the reduction of somatostatin-like immunoreactivity in LEC rats with hepatic encephalopathy may be caused by a decrease in production of prosomatostatin rather than altered degradation."
12/01/1988 - "These results imply that reduced somatostatin immunoreactivity in hepatic encephalopathy may be caused not by altered degradation but by reduced production of prosomatostatin. "
|5.||Alzheimer Disease (Alzheimer's Disease)
01/01/2003 - "The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease."
08/18/1986 - "The relative proportions of both somatostatin-14 and its precursors somatostatin-28 and the 15 Kdalton prosomatostatin were evaluated by radioimmunoassay in the cerebrospinal fluid of patients with Alzheimer's disease. "
01/01/2003 - "Since the two proprotein convertases (PC)1 and PC2 are responsible for the processing of neuropeptide precursors directed to the regulated secretory pathway, we examined whether they are involved first in the proteolytic processing of prosomatostatin in mouse and human brain and secondly in somatostatin defect associated with Alzheimer's disease. "
|1.||Somatostatin (Somatotropin Release-Inhibiting Factor)
|4.||Complementary DNA (cDNA)
|5.||Messenger RNA (mRNA)
|6.||Calcitonin (Calcitonin, Eel)
|7.||Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
|10.||Immune Sera (Antisera)