halofantrine (Halfan)

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180 relevant articles (37 outcomes, 24 trials/studies) found for this Drug

Description: used in treatment of mild to moderate acute malaria

Also Known As:

Halfan; 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl; GlaxoSmithKline brand of halofantrine hydrochloride; SmithKline Beecham brand of halofantrine hydrochloride; SmithKline brand of halofantrine hydrochloride; WR 171,699; WR 171669; WR-171,669; WR-171699; halofantrine hydrochloride

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

Hydrocarbons: 382

Cyclic Hydrocarbons: 2

Aromatic Hydrocarbons: 115

Aromatic Polycyclic Hydrocarbons: 581

Phenanthrenes: 6

halofantrine: 180

Polycyclic Compounds: 58

Aromatic Polycyclic Hydrocarbons: 581

Phenanthrenes: 6

halofantrine: 180

Experts

1.	Falade, C O: 1 article (12/2006)
2.	Fehintola, F A: 1 article (12/2006)
3.	Sowunmi, A: 1 article (12/2006)
4.	Krishna, Sanjeev: 1 article (08/2006)
5.	Valderramos, Juan-Carlos: 1 article (08/2006)
6.	Uhlemann, Anne-Catrin: 1 article (08/2006)
7.	Valderramos, Stephanie G: 1 article (08/2006)
8.	Fidock, David A: 1 article (08/2006)
9.	Sidhu, Amar Bir Singh: 1 article (08/2006)
10.	Ahmed, Tahir Masood: 1 article (07/2006)

Related Diseases

1.	Malaria 01/01/1993 - "Halofantrine was found to be highly effective in acute malaria and offers an important alternative to existing medications." 07/01/1992 - "We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects" 01/30/1988 - "At the 2 dosage levels tested halofantrine proved highly effective in the treatment of malaria caused by resistant and sensitive strains to P" 03/01/1995 - "We conclude that halofantrine is a quite safe and effective new antimalarial agent in the treatment of Pf malaria cases." 07/01/1993 - "If parenteral formulations of halofantrine prove to be safe and effective, they may have a role in the therapy of severe malaria." Get all the results and reference details, order at left...
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 09/01/1999 - "Halofantrine has been shown to be very effective against multiple drug resistant falciparum malaria" 08/01/1994 - "Halofantrine is a phenanthrenemethanol antimalarial that is effective against asexual forms of multidrug-resistant Plasmodium falciparum malaria" 09/01/1993 - "Micronized halofantrine appears to be a safe, well-tolerated, and effective treatment for acute falciparum malaria in semiimmune patients." 09/01/1991 - "The study confirms the efficacy of halofantrine hydrochloride as a blood schizonticide in falciparum malaria." 01/25/1997 - "Efficacy of low-dose halofantrine for second treatment of uncomplicated falciparum malaria." Get all the results and reference details, order at left...
3.	Infection 10/17/1998 - "Type R1 halofantrine resistance or successive infections by 2 different strains?]" 01/01/1996 - "Because of the documented high infection prevalence and the probable presence of many subpatent infections, all nonpregnant refugees were treated with halofantrine; those with P" 08/01/1993 - "falciparum infection were treated with 3 doses of halofantrine (500 mg each) orally, after food, at intervals of 6 hours" 01/01/2004 - "Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum malaria Infection." 01/01/1991 - "Halofantrine hydrochloride was found to be highly effective and appeared to have no side effects in children with acute malaria infections." Get all the results and reference details, order at left...
4.	Vivax Malaria 01/30/1988 - "Efficacy of halofantrine in Plasmodium falciparum or Plasmodium vivax malaria in a resistance area (French Guiana)]" 12/01/1995 - "Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine." 12/01/1995 - "In the present paper, we discuss the first Japanese vivax malaria patient whose QT interval was prolonged after treatment with halofantrine." 01/01/1997 - "On average, fever associated with falciparum or vivax malaria cleared 17 h faster with halofantrine-primaquine (P < 0.01) although there were no significant differences (P > 0.4) in parasite-clearance times between the two regimens" 01/01/1997 - "Of the 40 cases of falciparum malaria and 26 cases of vivax malaria treated with halofantrine-primaquine, none had a recurrent parasitaemia (100% efficacy)" Get all the results and reference details, order at left...
5.	Parasitemia 01/01/1994 - "A second course of therapy with halofantrine resulted in prompt clearance of parasitemias in all of these children" 06/01/2000 - "Three halofantrine recipients had initial clearance but subsequent recurrence of their parasitemias" 03/01/1990 - "54 children (mean age: 43 months), with initial parasitemia up to 1,000 Plasmodium falciparum isolates per mm3, were treated with halofantrine hydrochloride 8 mg/kg twice daily at 6 hours intervals" 10/01/1991 - "Patients who were cured by halofantrine had parasites that were more sensitive in in vitro testing to mefloquine (mean [inhibitory concentration] IC50 = 12.5 ng/ml) than in patients whose parasitemias recrudesced (mean IC50 = 23.8 ng/ml) (P less than 0.01, by Wilcoxon rank sum test)" 10/01/1995 - "Different methods for predicting late recrudescence were compared for 52 patients whose parasitemia initially cleared after treatment with either halofantrine or quinine" Get all the results and reference details, order at left...
49 Diseases and 180 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Mefloquine (Lariam)
3.	Quinine (Quinson)
4.	sulfadoxine-pyrimethamine (Fansidar)
5.	Pyrimethamine (Daraprim)
6.	Amodiaquine (Camoquin)
7.	artesunate
8.	artemether
9.	metakelfin
10.	Primaquine
65 Drugs and Important Bio-Agents and 95 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Chemoprevention
3.	Retreatment
4.	Drug Therapy (Chemotherapy)
5.	Self Medication
5 Therapies and Procedures and 12 more articles analyzed in the Research Interface, order at left...

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