Quinine (Quinson)

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1622 relevant articles (151 outcomes, 194 trials/studies) found for this Drug

Description: An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Also Known As:

Quinson; Alphapharm Brand of Quinine Sulfate; Aventis Brand of Quinine Bisulfate; Biquinate; Fawns & McAllan Brand of Quinine Bisulfate; Fawns & McAllan Brand of Quinine Sulfate; Foy Brand of Quinine Sulfate; Hoechst Brand of Quinine Sulfate; Innotech Brand of Quinine Hydrochloride; Lafran Brand of Quinine Hydrochloride; Legatrim; Myoquin; Odan Brand of Quinine Sulfate; Plough Brand of Quinine Sulfate; Prosana Brand of Quinine Bisulfate; Quinamm; Quinbisan; Quinbisul; Quindan; Quinimax; Quinine Bisulfate; Quinine Hydrochloride; Quinine Lafran; Quinine Sulfate; Quinine Sulphate; Quinine-Odan; Quinoctal; Quinsul; Strema; Surquina; Bisulfate, Quinine; Hydrochloride, Quinine; Sulfate, Quinine; Sulphate, Quinine; Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25

Experts

1.	Elbashir, M I: 8 articles (02/2007 - 12/2002)
2.	Adam, I: 8 articles (02/2007 - 12/2002)
3.	White, N J: 7 articles (11/2003 - 09/2000)
4.	Looareesuwan, Sornchai: 5 articles (11/2006 - 03/2003)
5.	Looareesuwan, S: 5 articles (11/2003 - 09/2000)
6.	Pussard, Eric: 4 articles (07/2006 - 01/2003)
7.	Pukrittayakamee, S: 4 articles (11/2003 - 09/2000)
8.	Wanwimolruk, S: 4 articles (11/2003 - 07/2000)
9.	Barennes, Hubert: 3 articles (12/2007 - 11/2004)
10.	Parola, Philippe: 3 articles (09/2007 - 04/2002)

Related Diseases

1.	Malaria 07/01/2009 - "Therefore, ACTs and not quinine should be used as second-line treatment, because these are well tolerated, highly efficacious, and have the advantage of reducing gametocyte carriage and consequently malaria transmissibility, particularly in areas of less intense transmission." 01/01/2000 - "Quinine by intramuscular or intrarectal injection has been found to be the best treatment for malaria in Niger, particularly in field health centres where the use of solutions can pose problems. " 03/01/1991 - "So, at the dosage of 25 mg/kg, quinine was found to be very effective in the Congo in 1989 against both pernicious and non pernicious malaria." 01/01/1995 - "The good tolerability and efficacy of this new intrarectal quinine formulation might allow to propose this route as an alternative to intramuscular route for the treatment of childhood malaria in Africa." 01/01/1995 - "High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic." Order ALL the reference details at left...
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 02/01/2006 - "Parenteral quinine is the most frequently used first line treatment for severe Plasmodium falciparum malaria in the developed world. " 02/19/1983 - "Parenteral quinine is the most effective treatment for severe falciparum malaria. " 03/01/2002 - "We have earlier obtained good results in falciparum malaria by treating children with low doses of quinine for 7 days in Guinea-Bissau. " 06/01/1990 - "A safe and effective consecutive-infusion regimen for rapid quinine loading in severe falciparum malaria." 02/20/1971 - "Resistant Plasmodium falciparum malaria cured by high quinine dosage." Order ALL the reference details at left...
3.	Infection 02/01/2004 - "In vivo studies revealed that 4-week intraventricular infusion of quinine or biquinoline was effective in prolonging the incubation period in experimental mouse models of intracerebral infection. " 12/01/2007 - "It is interesting to note that the FC27 genotype was overrepresented in ASUM (68.2%) and was not recognized in fatal CM, while in mixed-clone infections, the clearance of IC1 after quinine treatment was faster than FC27 clearance. " 04/01/1989 - "To examine the clinical and parasitologic efficacy of quinine, we studied 34 children (7 months-13 years old) with severe or moderately severe Plasmodium falciparum infections. " 11/01/2008 - "OBJECTIVES: This preliminary study sought to investigate the response of uncomplicated falciparum infections to semi-supervised drug administration with quinine and two adjunctive schizontocidal drugs in infected patients in Guyana. " 01/01/2003 - "The studies were conducted in June-August 2001 at Mae Sot, northwestern Thailand, an area where quinine alone is no longer able to eliminate infections with P. " Order ALL the reference details at left...
4.	Parasitemia 09/01/1991 - "Initial parasitemias were eradicated by a curative treatment with quinine, a drug with a short elimination half-life, to minimize the effects of residual drug on reinfection. " 09/01/2005 - "The time to a 4-log reduction of the initial level of parasitemia (Ter) was related to the average quinine concentration from 0 to 72 h (Cav) as Ter = Tmin [1 + (C50/Cav)s], where sigmoidicity (s) is equal to 2, Tmin is the time to eradication at infinite Cav, and C50 is the value of Cav for which Ter is twice Tmin. " 09/01/2005 - "Quinine concentrations in plasma samples (five to nine per patient) were measured by liquid chromatography on days 1 to 3. Parasitemia was counted on days 0, 1, 2, 3, 4, 7, and 14. " 08/01/2005 - "The therapeutic response to quinine treatment was comparable between patients with (CS)CM and CM. In conclusion, uniquely in this setting, CM can be associated with sub-patent parasitemia; thus, a diagnostic tool more sensitive than microscopy is needed." 08/01/2005 - "Pregnant women participating in a longitudinal immuno-epidemiologic survey in Lambaréné, Gabon, and presenting with Plasmodium falciparum parasitemia at monthly blood smear examinations were offered treatment with oral 7-day quinine monotherapy according to national health guidelines. " Order ALL the reference details at left...
5.	Cerebral Malaria 12/01/1990 - "Quinine is emerging as the only effective treatment for cerebral malaria, though resistance to this drug threatens to become a problem. " 06/01/2002 - "OBJECTIVE: To compare in a randomized study the efficacy and the toxicity of the new WHO intravenous quinine treatment of cerebral malaria including a loading dose regimen to a regimen without loading dose. " 07/01/1998 - "An open randomized clinical study of intrarectal versus infused Quinimax for the treatment of childhood cerebral malaria in Niger." 01/01/1998 - "METHOD: The study population consisted of 26 Zambian children < 6 years of age who presented with cerebral malaria to a rural hospital in 1994 and who were treated with quinine for seven days. " 09/01/1994 - "Delay in diagnosis and initiation of treatment with quinine adversely affected the prognosis of cerebral malaria in the study group." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	artemether
3.	Mefloquine (Lariam)
4.	sulfadoxine-pyrimethamine (Fansidar)
5.	artesunate
6.	Quinine (Quinson)
7.	Pyrimethamine (Daraprim)
8.	Tetracycline (Achromycin)
9.	artemisinine (artemisinin)
10.	halofantrine (Halfan)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intramuscular Injections
3.	Aftercare (After-Treatment)
4.	Retreatment
5.	Platelet Transfusion (Blood Platelet Transfusions)

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