ammonium 2,3,3,3- tetrafluoro- 2- (heptafluoropropoxy)- propanoate

GenX a trade name for a chemical process to produce an alternative to a perfluorooctanoic acid (PFOA or C8) in the synthesis of PTFE

Also Known As:

2,2,3-trifluoro-3-(trifluoromethyl)oxirane; 2,3,3,3-Tetrafluoro-2-(1,1,2,2,3,3,3,heptafluoropropoxy)propanoic acid; 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propanoic acid; 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate; 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid; 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid; C6HF11O3.H3N; GenX ammonium perfluoro-2-methyl-3-oxahexanoate; GenX perfluoro(2-propoxypropanoate); GenX perfluoro-2-methyl-3-oxahexanoic acid; GenX potassium salt; GenX-K; GenX-Na; HFPO hexafluoropropylene oxide; HFPO-DA; HFPO-DA hexafluoropropylene oxide dimer acid; HFPO-TA; HFPO-TA hexafluoropropylene oxide trimer acid; HFPO-TeA; HFPO-TeA hexafluoropropylene oxide tetramer acid; HFPO-TrA; HFPO-TrA hexafluoropropylene oxide trimer acid; HFPO2 compound; PFEA per- and polyfluoroalkyl ether acids; ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate; ammonium 2-(perfluoropropoxy)perfluoropropionate; ammonium perfluoro(2-methyl-3-oxahexanoic) acid; ammonium perfluoro-2-methyl-3-oxahexanoate; azanium;2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propanoate; hexafluoroepoxypropane; hexafluoropropene oxide; hexafluoropropylene oxide; hexafluoropropylene oxide dimer acid; hexafluoropropylene oxide tetramer acid; hexafluoropropylene oxide trimer acid; per- and polyfluoroalkyl ether acids; perfluoro(2-propoxypropanoate); perfluoro-2-(propyloxy)propionic acid; perfluoro-2-methyl-3-oxahexanoic acid; perfluoro-2-propoxypropanoic acid; perfluoro-2-propoxypropionic acid; potassium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate; propanoic acid, 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)-, potassium salt (1:1); propanoic acid, 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)-, sodium salt (1:1); sodium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Conley, Justin M: 2 articles (01/2022 - 01/2021)
2.	Evans, Nicola: 2 articles (01/2022 - 01/2021)
3.	Gray, L Earl: 2 articles (01/2022 - 01/2021)
4.	Hill, Donna: 2 articles (01/2022 - 01/2021)
5.	Lambright, Christy S: 2 articles (01/2022 - 01/2021)
6.	McCord, James: 2 articles (01/2022 - 01/2021)
7.	Medlock-Kakaley, Elizabeth: 2 articles (01/2022 - 01/2021)
8.	Strynar, Mark J: 2 articles (01/2022 - 01/2021)
9.	Blake, Bevin E: 1 article (01/2022)
10.	Fenton, Suzanne E: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2024 - "Association of adverse fetal outcomes with placental inflammation after oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in Sprague-Dawley rats." 12/20/2023 - "In conclusion, our investigation elucidates the role of HFPO-TA in inducing necroptosis and inflammation in the liver, which is facilitated through the activation of the W/β/NF-κB axis." 12/20/2023 - "Finally, we demonstrated that the phosphorylated form of NF-κB p65 (p-NF-κB p65) played a role in mediating the necroptosis and inflammation, and its activity could be regulated by the W/β signaling pathway in the liver of mice and HepG2 cells exposed to HFPO-TA. " 12/20/2023 - "Subsequently, we established that the W/β signaling mediated the necroptosis and inflammation observed in the liver and HepG2 cells exposed to HFPO-TA. " 12/01/2021 - "Taken together, all these results indicate the potential gut toxicity of HFPO-DA and is perceived as a major problem of health risk that affects the inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals."
2.	Cardiotoxicity 03/15/2023 - "HFPO-TeA exposure in chicken embryo resulted in developmental cardiotoxicity and hepatotoxicity. " 12/01/2021 - "In summary, developmental exposure to HFPO-DA induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens similar to PFOA, and PPARα still participates in such toxicities, with some differential downstream gene regulations in different organs. " 12/01/2021 - "The results indicated that developmental exposure to HFPO-DA induced developmental cardiotoxicity, including thinned right ventricular wall and elevated heart rates, similar to those observed with PFOA exposure, as well as developmental hepatotoxicity in the form of steatosis. " 12/01/2021 - "In the current study, potential developmental cardiotoxicity and hepatotoxicity following HFPO-DA exposure in chicken embryo has been investigated, focusing on the roles of peroxisome proliferator activated receptor alpha (PPARα), the major molecular target in PFOA-induced toxicities. " 12/01/2021 - "Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha."
3.	Hepatomegaly 07/01/2023 - "The liver index showing hepatomegaly rose significantly after 90 d of exposure to PFOA and HFPO-DA, respectively. " 01/01/2021 - "Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat."
4.	Edema (Dropsy) 07/01/2023 - "At the same LC50 toxicological effect, exposure to PFOA and HFPO-TA resulted in abnormal phenotypes such as spinal curvature, pericardial edema and aberrant body length, while Gen-X was little changed. " 03/01/2023 - "Spinal deformities and edema phenotypes were evident among embryos exposed to 1000-16,000 mg/L HFPO-DA at 72 hpf. "
5.	Overweight 01/01/2023 - "In this group of women, environmental exposure to a PFAS mixture was associated with an elevated odds of PCOS, with 6:2 Cl-PFESA, HFPO-DA, Σ3,4,5m-PFOS, and PFDoA being the major contributors, especially in overweight/obese women. "

Related Drugs and Biologics

1.	ammonium 2,3,3,3- tetrafluoro- 2- (heptafluoropropoxy)- propanoate
2.	PPAR alpha
3.	Catenins
4.	Cyclin D1
5.	Thyroid Hormones
6.	Messenger RNA (mRNA)
7.	Liver Glycogen
8.	Lipids
9.	Glucose (Dextrose)
10.	Fluorides