Abstract |
The in vitro modulation of apoptosis and cell proliferation by modified in comparison with non-modified ribonucleosides was investigated for the first time using peripheral blood lymphocytes, HL-60 cells and Caco-2 cells as human cell culture models. Modulating effects of several ribonucleosides were found in the range of 10(-7)-10(-3) mol/l. The following ribonucleosides induced significant apoptosis of HL-60 cells: adenosine, N6-dimethyladenosine, N6-(2-isopentenyl)-adenosine, N2-dimethylguanosine. A significant apoptotic effect on PBL was found with N6-dimethyladenosine and N6-(2-isopentenyl)-adenosine. N6-Dimethyladenosine, N6-(2-isopentenyl)-adenosine and guanosine had a pronounced inhibitory effect on Caco-2 cell apoptosis. Regarding the known function of ribonucleosides as pathobiochemical marker molecules for cancer, the possibility of a selective apoptotic effect against malignant cells is discussed.
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Authors | H Meisel, S Günther, D Martin, E Schlimme |
Journal | FEBS letters
(FEBS Lett)
Vol. 433
Issue 3
Pg. 265-8
(Aug 21 1998)
ISSN: 0014-5793 [Print] England |
PMID | 9744808
(Publication Type: Journal Article)
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Chemical References |
- Ribonucleosides
- Guanosine
- Inosine
- Isopentenyladenosine
- Adenosine
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Topics |
- Adenosine
(analogs & derivatives, pharmacology)
- Apoptosis
(drug effects)
- Cells, Cultured
- Colonic Neoplasms
- Guanosine
(analogs & derivatives, pharmacology)
- HL-60 Cells
(cytology, drug effects)
- Humans
- Inosine
(analogs & derivatives, pharmacology)
- Isopentenyladenosine
(pharmacology)
- Kinetics
- Lymphocytes
(cytology, drug effects, physiology)
- Ribonucleosides
(pharmacology)
- Tumor Cells, Cultured
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