Pyridoxine-responsive PH1: treatment.

Abstract

Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not to normal level-in the remaining 30%. In a few aneodotical cases pyridoxine administration was reported to improve kidney function in patients with renal failure secondary to hyperoxaluria. It is reminded that megadoses of pyridoxine (0.5 to 6 g daily) may induce severe sensory neuropathy.

• Authors: C Toussaint
• Journal: Journal of nephrology (J Nephrol) 1998 Mar-Apr Vol. 11 Suppl 1 Pg. 49-50 ISSN: 1121-8428 [Print] Italy
• PMID: 9604811 (Publication Type: Journal Article, Review)

Chemical References

• Pyridoxine

Topics

• Female
• Humans
• Hyperoxaluria, Primary (drug therapy)
• Kidney Failure, Chronic (prevention & control)
• Male
• Pyridoxine (adverse effects, therapeutic use)