Abstract | BACKGROUND: METHODS: The effect of dexamethasone on pulmonary metastasis of MRMT-1 cells and on the number of peripheral lymphocytes was evaluated in rats. To evaluate the suppressive effect of adrenalectomy and metyrapone treatment on operation-induced enhancement of metastasis, several parameters such as induction of pulmonary metastasis, serum corticosterone levels, and the number of blood lymphocytes and apoptotic thymocytes were determined. RESULTS: With dexamethasone treatment, the number of peripheral lymphocytes rapidly decreased; in contrast, pulmonary metastasis increased. The serum corticosterone level was doubled at 1 hour, apoptotic thymocyte numbers were increased about sevenfold at 3 hours and about fourfold at 6 hours, and blood lymphocyte numbers were decreased at 3 hours after laparotomy, which facilitated about a 10-fold increase in the pulmonary metastasis. These changes were almost completely suppressed by preoperative adrenalectomy and metyrapone treatment. CONCLUSIONS:
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Authors | M Deguchi, Y Isobe, S Matsukawa, A Yamaguchi, G Nakagawara |
Journal | Surgery
(Surgery)
Vol. 123
Issue 4
Pg. 440-9
(Apr 1998)
ISSN: 0039-6060 [Print] United States |
PMID | 9551071
(Publication Type: Journal Article)
|
Chemical References |
- Corticosterone
- Metyrapone
|
Topics |
- Adrenalectomy
- Animals
- Apoptosis
- Corticosterone
(blood)
- Female
- Leukocyte Count
- Lung Neoplasms
(pathology, prevention & control, secondary)
- Lymphocyte Count
- Mammary Neoplasms, Experimental
(blood, pathology, physiopathology, surgery)
- Metyrapone
(therapeutic use)
- Neoplasm Metastasis
(physiopathology, prevention & control)
- Rats
- Rats, Sprague-Dawley
- Stress, Physiological
- Surgical Procedures, Operative
(adverse effects)
- Thymus Gland
(pathology)
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