Abstract | PURPOSE: METHODS: RESULTS: At diagnosis, 8 patients had large lesions (>8 cm) and 3 had pulmonary metastases (1 with large tumor). Surgical resection was performed at diagnosis for 9 patients and after induction therapy for 5. During window therapy, all of the 9 evaluable patients responded (8 partial, I objective), and no patient without measurable disease developed disease progression. Responses were maintained or improved during subsequent induction in six of the patients with residual disease. Fourteen patients received local radiotherapy. At 49 to 94 months after diagnosis, 12 patients are disease-free (1 in second remission), 4 have died, and 1 is alive with disease. The five-year overall and progression-free survival rates are 77 +/- 13% and 62 +/- 16%, respectively. CONCLUSION: The use of consistent Ewing's-directed combined-modality therapy for patients with soft tissue peripheral PNET/EOE results in survival similar to that of patients with osseous Ewing's tumor. The combination of ifosfamide and etoposide appears active and should be incorporated in future treatment protocols.
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Authors | S Gururangan, N M Marina, X Luo, D M Parham, C Y Tzen, C A Greenwald, B N Rao, L E Kun, W H Meyer |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
1998 Jan-Feb
Vol. 20
Issue 1
Pg. 55-61
ISSN: 1077-4114 [Print] United States |
PMID | 9482414
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adolescent
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child
- Child, Preschool
- Combined Modality Therapy
- Female
- Humans
- Male
- Neuroectodermal Tumors
(therapy)
- Sarcoma, Ewing
(therapy)
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