Abstract | PURPOSE: METHODS: RESULTS: The keratitis worsened in both patients, despite intensive systemic and topical antifungal therapy. Both patients underwent therapeutic penetrating keratoplasties. In case 1, this resulted in successful resolution of the infection and no recurrences 3 months after the transplant. The corneal transplant was complicated by an expulsive choroidal hemorrhage in the other patient. Fusarium solani was cultured from the initial vitrectomy specimen in patient 1, and although it was not cultured from the keratitis, septate hyphal elements were present on histopathologic examination. The causative organism in case 2 was Acremonium kiliense, which was cultured from both the original vitrectomy specimen and the deep corneal stromal infiltrate. CONCLUSIONS: Fungal organisms may not be eradicated completely from eyes with endophthalmitis despite aggressive therapy and apparent initial successful treatment. These patients need to be monitored for prolonged periods, and treatment should be reinitiated at the earliest sign of recrudescence of infection.
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Authors | D J Weissgold, S E Orlin, M E Sulewski, W C Frayer, R C Eagle Jr |
Journal | Ophthalmology
(Ophthalmology)
Vol. 105
Issue 2
Pg. 258-62
(Feb 1998)
ISSN: 0161-6420 [Print] United States |
PMID | 9479284
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antifungal Agents
- Amphotericin B
- Fluconazole
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Topics |
- Acremonium
(isolation & purification)
- Aged
- Aged, 80 and over
- Amphotericin B
(therapeutic use)
- Antifungal Agents
(therapeutic use)
- Cataract Extraction
(adverse effects)
- Corneal Stroma
(microbiology)
- Endophthalmitis
(microbiology, pathology, therapy)
- Eye Infections, Fungal
(etiology, pathology, therapy)
- Female
- Fluconazole
(therapeutic use)
- Fusarium
(isolation & purification)
- Humans
- Keratitis
(microbiology, pathology, therapy)
- Keratoplasty, Penetrating
- Lenses, Intraocular
- Male
- Mycoses
(etiology, pathology, therapy)
- Retrospective Studies
- Vitrectomy
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