Abstract | BACKGROUND: METHODS: In this study, tracheas from Adriamycin-induced EA-TEF fetal rats were examined histologically and relevant cross-sectional parameters of the tracheas were measured. RESULTS: The tracheal lumen in tracheomalacia was small and irregular, losing its normal "D" shape. In most rats, the cartilaginous ring was broken into two to four segments, making the trachea lose its rigid support. The submucosa was thickened with prominent bulging of its membranous part into the tracheal lumen. The ratio of the inner luminal cross-sectional area to the outer tracheal cross-sectional area in EA-TEF rats was 15.7%, compared with a control ratio of 47.2%. In EA-TEF rats, the length of the cartilaginous ring was significantly shortened (P < .001), but not the length of membranous trachea, thus resulting in a cartilaginous/membranous (C/M) ratio of 1.55:1, markedly lower than that of normal rats (4.34:1, P < .001). The reduction of anterior-posterior diameter of the tracheal lumen was more marked than that of the transverse diameter. CONCLUSIONS:
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Authors | B Q Qi, J Merei, P Farmer, S Hasthorpe, J M Hutson, N A Myers, S W Beasley |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 32
Issue 11
Pg. 1575-9
(Nov 1997)
ISSN: 0022-3468 [Print] United States |
PMID | 9396529
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Airway Obstruction
(pathology)
- Animals
- Disease Models, Animal
- Embryonic and Fetal Development
- Esophageal Atresia
(pathology)
- Female
- Pregnancy
- Rats
- Rats, Sprague-Dawley
- Trachea
(growth & development, pathology)
- Tracheal Diseases
(pathology)
- Tracheoesophageal Fistula
(pathology)
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