Abstract |
The aim of the study was to distinguish infection from inflammation in patients with suspected infection using technetium-99m Infecton. Ninety-nine patients (102 studies) referred for infection evaluation underwent imaging with 400 MBq 99mTc-Infecton at 1 and 4 h. Most patients had appropriate microbiological tests and about half (56) had radiolabelled white cell scans as well. No adverse effects were noted in any patient. The clinical efficacy of 99mTc-Infecton depended in part on whether imaging was undertaken during antibiotic therapy for infection or not. In consultation with the microbiologist, 5-14 days of appropriate and successful antibiotic therapy was considered adequate to classify some results as true-negatives. The figures for sensitivity and specificity of 99mTc-Infecton for active or unsuccessfully treated infection were 83% and 91% respectively. It is concluded that 99mTc-Infecton imaging contributed to the differential diagnosis of inflammation. It is being used as the first imaging modality when bacterial infection is suspected.
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Authors | K E Britton, S Vinjamuri, A V Hall, K Solanki, Q H Siraj, J Bomanji, S Das |
Journal | European journal of nuclear medicine
(Eur J Nucl Med)
Vol. 24
Issue 5
Pg. 553-6
(May 1997)
ISSN: 0340-6997 [Print] Germany |
PMID | 9142737
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Ciprofloxacin
- Technetium
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Infective Agents
(therapeutic use)
- Bacterial Infections
(diagnostic imaging)
- Ciprofloxacin
(therapeutic use)
- Diagnosis, Differential
- Female
- Humans
- Inflammation
(diagnosis)
- Leukocytes
- Male
- Middle Aged
- Radionuclide Imaging
- Sensitivity and Specificity
- Technetium
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