The dopamine D3 receptor antagonist, (+)-S 14297, blocks the cataleptic properties of haloperidol in rats.

Abstract

In contrast to haloperidol, the selective dopamine D3 receptor antagonist, (+)-S 11566 [(+/-)-[7-(N,N-dipropylamino)-5,6,7,8-tetrahydro- naphtho(2,3b)dihydro,2,3-furanel]] and its active isomer, (+)-S 14297, induced neither catalepsy nor reduced conditioned avoidance responses in rats. (+)-S 11566 and (+)-S 14297 did, however, dose-dependently abolish the cataleptic actions of haloperidol. This action was expressed stereospecifically inasmuch as (-)-S 17777, the inactive distomer of (+)-S 14297, was ineffective. Further, the influence of haloperidol upon conditioned avoidance responses was not affected by (+)-S 14297. These data suggest that blockade of dopamine D3 receptors may inhibit the extrapyramidal but not-as based on the conditioned avoidance response paradigm-antipsychotic actions of neuroleptics.

• Authors: M J Millan, H Gressier, M Brocco
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 321 Issue 3 Pg. R7-9 (Mar 05 1997) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9085054 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antipsychotic Agents
• Dopamine D2 Receptor Antagonists
• Drd3 protein, rat
• Furans
• Receptors, Dopamine D3
• 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan
• 2-Naphthylamine
• Haloperidol

Topics

• 2-Naphthylamine (analogs & derivatives, pharmacology)
• Animals
• Antipsychotic Agents (toxicity)
• Avoidance Learning (drug effects)
• Catalepsy (chemically induced, physiopathology, prevention & control)
• Dopamine D2 Receptor Antagonists
• Dose-Response Relationship, Drug
• Furans (pharmacology)
• Haloperidol (toxicity)
• Male
• Rats
• Rats, Wistar
• Receptors, Dopamine D3
• Stereoisomerism