Bone resorption inhibitors from hop extract.

Abstract	We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
Authors	H Tobe, Y Muraki, K Kitamura, O Komiyama, Y Sato, T Sugioka, H B Maruyama, E Matsuda, M Nagai
Journal	Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 61 Issue 1 Pg. 158-9 (Jan 1997) ISSN: 0916-8451 [Print] England
PMID	9028043 (Publication Type: Journal Article)
Chemical References	Cyclohexenes Flavonoids Plant Extracts Propiophenones Terpenes humulon xanthohumol
Topics	Bone Resorption (drug therapy) Cyclohexenes Dose-Response Relationship, Drug Flavonoids Plant Extracts (chemistry, pharmacology) Plants, Edible (chemistry) Propiophenones (chemistry, pharmacology) Structure-Activity Relationship Terpenes (chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!