Ebastine is
H1 receptor antagonist, powerful and selective for
histamine. Its efficacy has been evaluated in control of symptoms of persistent
rhinitis, appearance of secondary effects and tolerance of the
drug, in 30 children who were suffering from persistent
rhinitis, of which the diagnosis included:- clinical history, skin tests (prick test) nasal and conjunctival provocation tests, total and specific
IgE. All the children had treatment for 30 days. The parameters followed were:- clinical score, skin tests, nasal and conjunctival provocations and evaluation of secondary effects, of the start and 10 days after the end of treatment. The results obtained were a disappearance or reduction of the weals from
histamine and specific
antigens, disappearance or reduction of the response in nasal and conjunctival provocation with
carbachol or specific
antigens, clear clinical improvement in 22 patients, in 2 small improvement and no response in 6 patients. We conclude that
Ebastine improved the clinical symptoms in persistent
rhinitis, the skin test is inhibited and sensitivity of the
shock organ is reduced. No secondary effects were seen on the Central Nervous System (SNC) and the tolerance of the
drug was very good.