New NO-donors with antithrombotic and vasodilating activities, part 15 nitrolic acids.

Abstract

Five 1-oximino-1-nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1-Nitro-ethanone 1-oxime (1, ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 degrees C nearly exclusively gave N2O and acetic acid indicating that HNO primarily had been formed.

• Authors: K Rehse, M Herpel, D Piechocki
• Journal: Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 329 Issue 2 Pg. 83-6 (Feb 1996) ISSN: 0365-6233 [Print] Germany
• PMID: 8851471 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Vasodilator Agents

Topics

• Animals
• Blood Pressure (drug effects)
• Fibrinolytic Agents (chemical synthesis, pharmacology)
• Male
• Rats
• Rats, Inbred SHR
• Rats, Wistar
• Vasodilator Agents (chemical synthesis, pharmacology)