Simple analysis of plasmalogens in erythrocytes using gas chromatography/mass spectrometry with selected-ion monitoring acquisition.

Abstract

Plasmalogens are a unique class of ether-phospholipids whose role, even though not fully defined, is essential. Their biosynthesis starts in peroxisomes, therefore, plasmalogen analysis is fundamental in the study of peroxisomal disorders. The present work reports a simple method for plasmalogen determination in erythrocytes for use in the study of peroxisomal disorders in humans; the procedure is based on two other methods that have previously been reported and employs GC/MS for separation and detection.

• Authors: U Caruso
• Journal: Rapid communications in mass spectrometry : RCM (Rapid Commun Mass Spectrom) Vol. 10 Issue 10 Pg. 1283-5 ( 1996) ISSN: 0951-4198 [Print] England
• PMID: 8759335 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetals
• Fatty Acids
• Plasmalogens

Topics

• Acetals (blood)
• Erythrocytes (chemistry)
• Fatty Acids (blood)
• Gas Chromatography-Mass Spectrometry
• Humans
• Magnetic Resonance Spectroscopy
• Plasmalogens (blood)