Expression of c-fms proto-oncogene product by ovarian cancer cell lines with effects of macrophage colony-stimulating factor on proliferation.

Abstract

We studied the production of macrophage colony-stimulating factor (M-CSF) and the expression of c-fms mRNA, an M-CSF receptor, in four human ovarian cancer cell lines. All four cell lines expressed c-fms mRNA while three secreted M-CSF into the culture medium. The exogenous administration of M-CSF caused no significant enhancement of cellular proliferation in any cell line. Interestingly, the proliferation of KK cells was not affected by anti-M-CSF antibody. These results, taken together with the fact that ovarian cancer cells simultaneously produce M-CSF and c-fms, suggest that an autocrine mechanism may modulate cellular proliferation.

• Authors: M Suzuki, I Sekiguchi, M Ohwada, I Sato, T Matsui, T Tanabe, S Hashimoto, M Yamada
• Journal: Oncology (Oncology) 1996 Mar-Apr Vol. 53 Issue 2 Pg. 99-103 ISSN: 0030-2414 [Print] Switzerland
• PMID: 8604248 (Publication Type: Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• MAS1 protein, human
• Oncogene Protein gp140(v-fms)
• Proto-Oncogene Mas
• RNA, Messenger
• Macrophage Colony-Stimulating Factor

Topics

• Adenocarcinoma (metabolism, pathology)
• Antibodies, Anti-Idiotypic (pharmacology)
• Cell Division (drug effects)
• Female
• Humans
• Macrophage Colony-Stimulating Factor (biosynthesis, immunology, pharmacology)
• Oncogene Protein gp140(v-fms) (biosynthesis)
• Ovarian Neoplasms (metabolism, pathology)
• Proto-Oncogene Mas
• RNA, Messenger (biosynthesis)
• Tumor Cells, Cultured