Abstract |
Manganese-tetrasulfonated phthalocyanine (MnPcS4) has been evaluated as a potential contrast agent in Magnetic resonance imaging (MRI) for tumor localisation in mice. MnPcS4 showed favourable molar relaxivity, much better than Gd-DTPA and comparable to tetrasulfonated manganese complex of porphyrin ( TPPS4). Tumors showed selective retention of the metal complex ( dye) with the peak value reached at 24 hours following intravenous administration. Dye concentration in tumors remained consistently higher than either kidney or muscle tissue both at 1 and 24 hours and a 10-fold increase in tumor-to-muscle ratio over the control was seen at 24 hr. Normal liver tissue, however, showed higher concentration than tumor at all times during the study. A linear correlation was found between longitudinal relaxation rate (1/T1) and the corresponding concentration of MnPcS4 in various tissues. MR imaging done in animals using 1.5 T superconducting clinical imager showed a mean percent increase in signal intensity of 131.8% (SD +/- 32.86) in the tumor and a 70% increase in tumor-to-muscle ratio over the pretreatment value, at 24 hr. The results suggest that MnPcS4 is a potential tumor-selective contrast agent in MRI.
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Authors | S K Saini, A Jena, J Dey, A K Sharma, R Singh |
Journal | Magnetic resonance imaging
(Magn Reson Imaging)
Vol. 13
Issue 7
Pg. 985-90
( 1995)
ISSN: 0730-725X [Print] Netherlands |
PMID | 8583877
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Indoles
- Organometallic Compounds
- Manganese
- manganese tetrasulfophthalocyanine
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Topics |
- Animals
- Contrast Media
- Female
- Indoles
(pharmacokinetics)
- Magnetic Resonance Imaging
(methods)
- Mammary Neoplasms, Experimental
(diagnosis)
- Manganese
(pharmacokinetics)
- Mice
- Mice, Inbred C3H
- Neoplasm Transplantation
- Organometallic Compounds
(pharmacokinetics)
- Time Factors
- Tissue Distribution
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