Functional and genetic analysis of annexin VI.

Abstract

This study is concerned with the determination of the function of the 68kDa calcium-binding protein, annexin VI. Studies on the structure and regulation of the gene include a detailed analysis of annexin VI expressed heterologously in human A431 carcinoma cells. We have recently discovered that annexin VI is subject to a novel growth dependent post-translational modification. Interestingly, the protein exerts a negative effect on A431 cells. This effect was manifested as a partial reversal of the transformed phenotype. We are currently exploring the hypothesis that the post-translational modification of annexin VI is required for sub-cellular targeting, and that correct localisation within the cell is essential for function.

• Authors: H C Edwards, S E Moss
• Journal: Molecular and cellular biochemistry (Mol Cell Biochem) 1995 Aug-Sep Vol. 149-150 Pg. 293-9 ISSN: 0300-8177 [Print] Netherlands
• PMID: 8569744 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Annexin A6

Topics

• Alternative Splicing
• Animals
• Annexin A6 (physiology)
• Cytoskeleton (metabolism)
• Genes
• Humans
• Mice
• Phosphorylation
• Repetitive Sequences, Nucleic Acid
• Tissue Distribution