Glutathione isopropyl ester (YM737) inhibits the progression of X-ray-induced cataract in rats.
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| Abstract |
The effect of glutathione (GSH) isopropyl ester on the progression of X-ray-induced cataract was investigated in rats. Intraperitoneal administration of 20 mg/kg GSH isopropyl ester, three times weekly, 1 day after a single irradiation dose delayed the progression of X-ray-induced cataracts significantly. The amount of non-protein SH groups and the Na+/K+ ratio in the lenses of drug-treated rats were maintained at the normal levels even 27 weeks after irradiation. Posttreatment with the drug resulted in a significantly lower level of malondialdehyde in the irradiated lenses than in the nontreated lenses. When 500 mg/kg GSH-isopropyl ester was administered by i.p. injection to normal rats, the GSH-ester was detected in plasma and aqueous humor after 15 min. In the lenses of the GSH-isopropyl ester-injected rats, the GSH level was 120% of that in the non-treated rats after 4 h, suggesting that GSH-isopropyl ester is transported from the aqueous humor to the lens and there converted to GSH after about 4 h. Our observations lead us to conclude that the delay of X-ray-induced lens opacity progression is due to maintenance of normal lenticular GSH levels achieved by post-irradiation administration of GSH-isopropyl ester. However, continuous administration of 100 mg/kg after irradiation had no effect on the progression of cataracts induced by X-rays.
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| Authors | S Kobayashi, M Kasuya, K Shimizu, Y Ishii, M Takehana, K Sakai, N Suzuki, M Itoi |
| Journal | Current eye research (Curr Eye Res) Vol. 12 Issue 2 Pg. 115-22 (Feb 1993) ISSN: 0271-3683 [Print] England |
| PMID | 8449022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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