Abstract | OBJECTIVE: To study in a randomized and longitudinal manner the efficacy of human menopausal gonadotropin (hMG) superovulation combined with intrauterine insemination (IUI) versus IUI alone in the treatment of various causes of infertility in the presence of normal ovulation. METHODS: An initially randomized and subsequently longitudinal study of infertile couples was performed at a university-based clinical research center. One hundred nineteen couples with longstanding infertility (average duration 3.7 years) associated with male factor infertility, unexplained infertility, and/or endometriosis were enrolled. All patients were randomized in the initial cycle to treatment with either hMG/IUI or urine LH-timed IUI alone. They were then followed longitudinally as they alternated subsequent cycles between the two modalities. Outcome indices measured were cycle fecundity, pregnancy outcome, and cumulative pregnancy rates evaluated by life-table analysis. RESULTS: CONCLUSION:
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Authors | J C Nulsen, S Walsh, S Dumez, D A Metzger |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 82
Issue 5
Pg. 780-6
(Nov 1993)
ISSN: 0029-7844 [Print] United States |
PMID | 8414326
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Female
- Follow-Up Studies
- Humans
- Infertility, Female
(therapy)
- Infertility, Male
- Insemination, Artificial
- Longitudinal Studies
- Male
- Menotropins
(therapeutic use)
- Pregnancy
(statistics & numerical data)
- Proportional Hazards Models
- Risk
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