[The use of sodium gamma-oxybutyrate and gutimine for decreasing metabolic disorders in the heart, caused by exotoxic shock in acetic acid poisoning].

Abstract

Exotoxic shock was simulated in non-linear rat males anesthetized with barbital after intragastric administration of 70% acetic acid at a dose of 4 ml/kg using a gastric tube. Energy metabolism and the rate of lipid peroxidation were studied in heart muscle during the decompensated and terminal periods of exotoxic shock. Sodium hydroxybutyrate (200 mg/kg) and gutimine (75 mg/kg), administered alone within 30 min after the poisoning, prolonged the period before manifestation of the decompensated and terminal steps of the shock; these drugs decreased the rate of metabolic impairments in the myocardium by decreasing the rates of adenine nucleotide catabolism, of glycolysis, lipolysis and lipid peroxidation.

• Authors: I N Petrin, V T Dolgikh, I P Krolevets
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1993 Nov-Dec Vol. 39 Issue 6 Pg. 36-9 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Primenenie gamm-oksibutirata natriia i gutimina dlia umen'sheniia metabolicheskikh narusheniĭ v serdtse, vyzvannykh ékzotoksicheskim shokom pri otravlenii ukusnoĭ kislotoĭ.
• PMID: 8303871 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acetates
• Adenine Nucleotides
• Antioxidants
• Hypoxanthines
• Hypoxanthine
• Sodium Oxybate
• Guanylthiourea
• Acetic Acid

Topics

• Acetates (poisoning)
• Acetic Acid
• Adenine Nucleotides (metabolism)
• Animals
• Antioxidants (pharmacology)
• Glycolysis
• Guanylthiourea (pharmacology)
• Heart (drug effects)
• Hypoxanthine
• Hypoxanthines (antagonists & inhibitors)
• Lipid Metabolism
• Lipid Peroxidation
• Male
• Myocardium (metabolism)
• Rats
• Shock, Septic (metabolism)
• Sodium Oxybate (pharmacology)