A comparative trial of hyposensitization in 1973 in the treatment of hay fever using Pollinex and Alavac-P.

Abstract

A direct comparison was made in 112 hay fever patients of hyposensitization treatment with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex) and with alum-precipitated pyridine extract (Alavac-P) which is an accepted form of treatment, its efficacy having been shown by a comparative trial against a placebo preparation. No significant difference could be detected between the results of the two forms of treatment. Seventy-seven per cent of patients responded with improvement following treatment with the tyrosine adsorbed vaccine, and 81% of those receiving the alum-precipitated vaccine. Side effects from treatment, both local and general, were generally of an infrequent or mild nature for both vaccines.

• Authors: A C Miller
• Journal: Clinical allergy (Clin Allergy) Vol. 6 Issue 6 Pg. 551-6 (Nov 1976) ISSN: 0009-9090 [Print] England
• PMID: 827393 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Aldehydes
• Alum Compounds
• Antigens, Plant
• Plant Extracts
• Pyridines
• Tyrosine
• Parietaria judaica pollen
• Glutaral

Topics

• Adolescent
• Adult
• Aldehydes (therapeutic use)
• Alum Compounds
• Antigens, Plant
• Child
• Clinical Trials as Topic
• Desensitization, Immunologic
• Female
• Glutaral (therapeutic use)
• Humans
• Male
• Middle Aged
• Plant Extracts
• Pollen
• Pyridines (therapeutic use)
• Rhinitis, Allergic, Seasonal (drug therapy)
• Tyrosine (therapeutic use)