[Labile arterial hypertension and sympathetic tonus. Hemodynamic study].

Abstract

Cardiac output, cardiopulmonary (CPBV) and total (TBV) blood volumes, vascular reactivity to norepinephrine and dopamine B hydroxylase (DBH) were determined in 41 borderline hypertensives patients in comparison with 28 normal subjects. Cardiac output (P less than 0.001) and CPBV/TBV ratio (P less than 0.01) were significantly increased. The ratio was directly correlated to the pressor-response to norepinephrine (P less than 0.01) and the DBH level (P less than 0.005). The results suggest that sympathetic overactivity plays a dominant role in the cardiac output elevation of borderline hypertensive patients.

• Authors: A Simon, J P Lehner, M Safar, J M Alexandre, Y Weiss, P Milliez
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 69 Issue 12 Pg. 1305-9 (Dec 1976) ISSN: 0003-9683 [Print] France
• Vernacular Title: Hypertension artérielle labile et tonus sympathique. Etude hémodynamique
• PMID: 827268 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dopamine beta-Hydroxylase
• Norepinephrine

Topics

• Adult
• Blood Pressure (drug effects)
• Blood Volume (drug effects)
• Cardiac Output (drug effects)
• Cardiac Volume (drug effects)
• Dopamine beta-Hydroxylase (pharmacology)
• Hemodynamics
• Humans
• Hypertension (physiopathology)
• Norepinephrine (pharmacology)
• Stimulation, Chemical
• Sympathetic Nervous System (physiopathology)