Graft-versus-leukemia effect in allogeneic bone marrow transplantation in mice against several radiation-induced leukemias.

Abstract

The intensity of graft-versus-leukemia (GVL) effect was studied using several radiation-induced leukemia cell lines (designated 8027, 8313, 9107, 7929) in MHC-compatible and -incompatible allogeneic bone marrow transplantation (BMT) of leukemia-bearing C3H mice. The results indicated that BMT from MHC-incompatible allogeneic (B10, B10.D2) donors consistently improved the survival of the treated mice compared with that in syngeneic (C3H) donors. However, BMT from MHC-compatible allogeneic (B10.BR, CBA, AKR) donors failed to improve the survival of 8027-bearing recipients. On the other hand, a remarkable improvement in survival of 8313, 9107 or 7929-bearing recipients was observed in MHC-compatible allogeneic (B10.BR, AKR) BMT but there was only a marginal GVL effect in MHC-compatible BMT from CBA donors. There was no clear correlation between the intensity of GVL effect and the amount of class I MHC molecules expressed on leukemic cell lines. The activity of donor lymph node cells for the induction of lethal graft-versus-host disease (GVHD) correlated with the intensity of GVL effect induced by intact donor bone marrow. The results indicate that GVL effect against radiation-induced leukemias could be consistently induced in MHC-incompatible allogeneic BMT whereas the intensity of GVL effect induced in MHC-compatible allogeneic BMT varied among different leukemias and the donor-host strain combinations used.

• Authors: S Aizawa, T Sado, H Kamisaku, K Nemoto, K Yoshida
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 13 Issue 2 Pg. 109-14 (Feb 1994) ISSN: 0268-3369 [Print] England
• PMID: 8205078 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histocompatibility Antigens Class I

Topics

• Animals
• Bone Marrow (pathology)
• Bone Marrow Transplantation (adverse effects, pathology)
• Flow Cytometry
• Graft vs Host Disease (epidemiology, immunology, physiopathology)
• Histocompatibility Antigens Class I (analysis)
• Incidence
• Leukemia, Experimental (epidemiology, immunology)
• Leukemia, Myeloid (epidemiology, immunology, therapy)
• Leukemia, Radiation-Induced (epidemiology, immunology, therapy)
• Lymph Nodes (pathology)
• Male
• Mice
• Mice, Inbred AKR
• Mice, Inbred C3H
• Mice, Inbred CBA
• Recurrence
• Survival Analysis
• Transplantation, Homologous