[Study of different states of iodine metabolism in rats by means of whole-body radiometry].

Abstract

The authors present the principal concepts necessary for the use of the method of radiometry of the whole body in studying the iodine metabolism in vivo in the intact and thyroidectomized rats and also in experimental hyperthyroidism resulting from TTH or thyroidin administration. The iodine metabolism indices in euthyroidism and athyroidism in rats proved to be adequate to the corresponding curves of the iodine metabolism indices in healthy persons and those suffering from myxedema. Experimental hyperthyroidism in rats, similarly to hyperthyroidism in man, was characterized by an increase in tissue metabolism of the hormonal iodine. However, it was accompanied by an accelerated clearance of the organism from an excess of thyroid hormones; due to this it could not serve as an adequate model of thyrotoxicosis in man.

• Authors: N A Spryshkova, L T Egorova, D G Palinkashi
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) Vol. 22 Issue 2 Pg. 70-5 ( 1976) ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Izuchenie razlichnykh sostoianiĭ ĭodnogo obmena u krys metodom radiometrii vsego tela
• PMID: 818632 (Publication Type: English Abstract, Journal Article)

Chemical References

• Iodine Radioisotopes
• Thyroid Hormones
• Thyrotropin
• Iodine

Topics

• Animals
• Disease Models, Animal
• Hyperthyroidism (chemically induced, metabolism)
• Iodine (metabolism)
• Iodine Radioisotopes
• Rats
• Thyroid Gland (metabolism)
• Thyroid Hormones (administration & dosage)
• Thyroidectomy
• Thyrotropin (administration & dosage)
• Time Factors
• Whole-Body Counting (instrumentation)