Analgesic efficacy and acceptability of fenoprofen combined with paracetamol and compared with dihydrocodeine tartrate in general practice.

Abstract

A single-blind between-patient study in general practice was made to examine the acceptability and analgesic efficacy of a combination of fenoprofen (200 mg) and paracetamol (500 mg) given 3 to 4 times daily for a period of 4 to 14 days in the treatment of acute and chronic pain. The combination was compared with dihydrocodeine tartrate (30 mg) in two groups of 75 patients suffering from a wide variety of presenting conditions, including osteo-arthritis, spondylitis, lumbago, sciatica, non-articular rheumatism and trauma. Clinical and patient assessment indicated that the combination was an effective analgesic combination, significantly better in success rate than dihydrocodeine tartrate and with a much lower incidence of side-effects (13% of patients receiving fenoprofen and paracetamol reported side-effects compared to 37% for the dihydrocodeine group). The combination demonstrated particular success in the treatment of non-articular rheumatism.

• Authors: J E Murphy, J F Donald, A Layes Molla
• Journal: The Journal of international medical research (J Int Med Res) Vol. 6 Issue 5 Pg. 375-80 ( 1978) ISSN: 0300-0605 [Print] England
• PMID: 81155 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Phenylpropionates
• Acetaminophen
• Fenoprofen
• Codeine

Topics

• Acetaminophen (adverse effects, therapeutic use)
• Adolescent
• Adult
• Aged
• Clinical Trials as Topic
• Codeine (adverse effects, analogs & derivatives, therapeutic use)
• Drug Therapy, Combination
• Female
• Fenoprofen (adverse effects, therapeutic use)
• Humans
• Joint Diseases (drug therapy)
• Male
• Middle Aged
• Palliative Care
• Phenylpropionates (therapeutic use)