Long-term follow-up of mitomycin C nephropathy.

Abstract

Two cases of mitomycin C nephropathy, which occurred after postoperative chemotherapy for advanced gastric cancer, were followed up for 6 (case 1) and 10 years (case 2). Hemolytic uremic syndrome developed 68 days (case 1) and 160 days (case 2) after the last administration of MMC with a total dose of 60 mg (case 1) and 40 mg (case 2). Serum creatinine levels were normalized in case 1 and they remained at about 2 mg/dl in case 2. Hyporeninemic hypoaldosteronism was transiently seen in case 2. These data suggest that recovery from the acute phase of hemolytic uremic syndrome leads to a good long-term prognosis in MMC nephropathy.

• Authors: Y Motoo, N Sawabu, K Ikeda, Y Takemori, H Ohta, T Okai, H Yokoyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 33 Issue 3 Pg. 180-4 (Mar 1994) ISSN: 0918-2918 [Print] Japan
• PMID: 8061399 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mitomycin
• Renin

Topics

• Hemolytic-Uremic Syndrome (chemically induced, pathology)
• Humans
• Hypoaldosteronism (blood, chemically induced)
• Kidney Diseases (chemically induced, pathology)
• Male
• Microscopy, Electron
• Middle Aged
• Mitomycin (adverse effects)
• Prognosis
• Renin (blood, deficiency)
• Stomach Neoplasms (drug therapy)
• Time Factors