Abstract |
The delayed-type allergenicity of triforine ( Saprol), 1,4-bis (2,2,2-trichloro-1-formamidoethyl) piperazine, was studied. In a mass examination of chrysanthemum growers among whom triforine was commonly used, the highest rate of positive patch test reaction was seen to triforine (17%) among the 7 pesticides and chrysanthemum extracts tested. A higher prevalence rate of work-related skin symptoms was seen in subjects with a positive patch test reaction to triforine (44%) than in those with negative reactions to all allergens tested (15%) (p < 0.05). 12 subjects (67%) with positive patch test reactions to triforine were also positive to dichlorvos ( DDVP), with a high kappa coefficient (0.65). The grading of guinea pig maximization test to triforine was grade IV (66%), defined as "strong". Cross-sensitization between triforine and dichlorvos was also shown. The present results confirm that triforine is capable of including delayed-type allergy among chrysanthemum growers and of showing cross-reactivity with dichlorvos.
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Authors | A Ueda, K Aoyama, F Manda, T Ueda, Y Kawahara |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 31
Issue 3
Pg. 140-5
(Sep 1994)
ISSN: 0105-1873 [Print] England |
PMID | 7821004
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fungicides, Industrial
- Piperazines
- Dichlorvos
- triforine
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Topics |
- Adult
- Animals
- Chrysanthemum cinerariifolium
- Cross Reactions
- Dermatitis, Allergic Contact
(etiology, immunology)
- Dermatitis, Occupational
(etiology, immunology)
- Dichlorvos
(adverse effects)
- Female
- Fungicides, Industrial
(adverse effects)
- Guinea Pigs
- Humans
- Hypersensitivity, Delayed
(chemically induced, immunology)
- Male
- Middle Aged
- Patch Tests
- Piperazines
(adverse effects)
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