Abstract | OBJECTIVES: METHODS: Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chi-squared test and the Student-Newman-Keuls test. RESULTS: A substantial improvement in symptoms was achieved in 20 (66.6%) patients in the testosterone group and in 21 (75%) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications. CONCLUSIONS:
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Authors | M Sideri, M Origoni, L Spinaci, A Ferrari |
Journal | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
(Int J Gynaecol Obstet)
Vol. 46
Issue 1
Pg. 53-6
(Jul 1994)
ISSN: 0020-7292 [Print] United States |
PMID | 7805984
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Ointments
- Testosterone
- Petrolatum
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Topics |
- Administration, Cutaneous
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Chi-Square Distribution
- Double-Blind Method
- Female
- Humans
- Lichen Sclerosus et Atrophicus
(drug therapy, pathology)
- Middle Aged
- Ointments
- Petrolatum
(therapeutic use)
- Prospective Studies
- Testosterone
(therapeutic use)
- Treatment Outcome
- Vulvar Diseases
(drug therapy, pathology)
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