Ogilvie's syndrome: a new approach to an old problem.

Abstract

PURPOSE:

This study was designed to determine the value of intravenous neostigmine in achieving adequate colonic decompression in patients with Ogilvie's syndrome.

METHODS:

A prospective study was undertaken in 12 consecutive patients (median age, 60 (range, 38-98) years) with contrast enema-proven Ogilvie's syndrome (median duration, four (range, two-nine) days)

RESULTS:

Satisfactory clinical decompression of large bowel distention was attained in 11 patients, although one required colectomy for subsequent recurrence and ischemia.

CONCLUSION:

These results support the theory that many cases of Ogilvie's syndrome are the result of excessive large bowel parasympathetic suppression rather than sympathetic overactivity.

• Authors: B M Stephenson, A R Morgan, J R Salaman, M H Wheeler
• Journal: Diseases of the colon and rectum (Dis Colon Rectum) Vol. 38 Issue 4 Pg. 424-7 (Apr 1995) ISSN: 0012-3706 [Print] United States
• PMID: 7720453 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Contrast Media
• Neostigmine

Topics

• Adult
• Aged
• Aged, 80 and over
• Colonic Pseudo-Obstruction (diagnosis, drug therapy, etiology)
• Contrast Media
• Dose-Response Relationship, Drug
• Drug Administration Routes
• Enema
• Female
• Humans
• Male
• Middle Aged
• Neostigmine (therapeutic use)
• Prospective Studies
• Sigmoidoscopy
• Treatment Outcome