Influence of imipramine on the circulatory system in the course of endogenous depressive syndromes. I. Evaluation of the basic parameters of the circulatory system.

Abstract

In patients with endogenous depression, imipramine exerts a regulative effect in both directions on blood pressure and pulse rate, dependent on the starting levels. In a majority of patients treated with imipramine, after 14 days blood pressure dropped and pulse rate was slowed. Remission of endogenous depression was statistically significantly more frequent in patients treated with imipramine in whom pressure and pulse rate underwent normalization. Early appearance of these effects of imipramine in patients with endogenous depression seems to be a good prognostic index.

• Authors: A Mrozikiewicz, Strzyzewski
• Journal: Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 23 Issue 6 Pg. 795-801 ( 1975) ISSN: 0004-069X [Print] Switzerland
• PMID: 769738 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Imipramine

Topics

• Adult
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Depression (drug therapy, physiopathology)
• Female
• Hemodynamics (drug effects)
• Humans
• Imipramine (pharmacology, therapeutic use)
• Male
• Middle Aged
• Time Factors