Abstract | OBJECTIVE: To evaluate the effect of serum from infertile women with endometriosis on fertilization and embryonic development in a murine IVF model. DESIGN: Pretreatment and post-treatment comparison of murine oocyte fertilization and early embryonic development with the addition of serum supplements from infertile women with endometriosis. SETTING: Tertiary care academic medical center. PATIENTS: RESULTS: When compared with serum from fertile women, serum from infertile women with endometriosis inhibited fertilization rates (51% versus 81%) and subsequent embryonic development rates (46% versus 79%). The inhibitory effect was greater as the stage of endometriosis increased. Treatment of endometriosis by laser laparoscopy improved both fertilization (51% versus 56%) and early embryonic development rates (46% versus 58%). CONCLUSIONS:
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Authors | K A Miller, D E Pittaway, J L Deaton |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 64
Issue 3
Pg. 623-6
(Sep 1995)
ISSN: 0015-0282 [Print] United States |
PMID | 7641919
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Animals
- Blood
- Embryonic and Fetal Development
- Endometriosis
(blood, complications, surgery)
- Female
- Fertilization in Vitro
- Humans
- Infertility, Female
(blood, complications)
- Laparoscopy
- Laser Therapy
- Mice
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