Reduction in bowel program duration with polyethylene glycol based bisacodyl suppositories.

Abstract

UNLABELLED:

The neurogenic bowel caused by spinal cord injury frequently requires a bowel program (BP) with stimulant suppositories for effective defecation.

OBJECTIVE:

The effectiveness of bowel programs initiated by hydrogenated vegetable oil based bisacodyl (HVB) suppositories was compared with that of polyethylene glycol based bisacodyl suppositories (PGB).

DESIGN:

Single subject, randomized treatment.

SETTING:

Outpatient.

SUBJECT:

Chronic T2 complete spinal cord injury (SCI).

INTERVENTION:

The suppository for the every third-day BP was randomized to PGB or HVB. The times in minutes of the following BP events were recorded: suppository insertion, first flatus, begin stool flow, end stool flow, and transfer off toilet.

OUTCOME MEASURES:

BP event times were used to derive BP intervals: suppository insertion to first flatus = Time to Flatus, first flatus until begin stool flow = Flatus to Stool Flow, begin stool flow until end stool flow = Defecation Period, end stool flow until the transfer off the toilet = Wait Until Transfer, and suppository insertion until transfer off the toilet = Total BP Time. The number of digital stimulations required and the amount of stool results were recorded.

RESULTS:

The data included two groups of BPs: HVB (N = 13) and PGB (N = 13). Wilcoxon's rank sum tests were used to compare mean times for each of the BP intervals: Time to Flatus (HVB 37 minutes, PGB 10 minutes, p < .0001), Flatus to Stool Flow (HVB 6.0 minutes, PGB 5.9 minutes, p = .9578), and the Defecation Period (HVB 31, PGB 21, p = .0043).(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: S A Stiens
• Journal: Archives of physical medicine and rehabilitation (Arch Phys Med Rehabil) Vol. 76 Issue 7 Pg. 674-7 (Jul 1995) ISSN: 0003-9993 [Print] United States
• PMID: 7605188 (Publication Type: Case Reports, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Drug Carriers
• Plant Oils
• Suppositories
• Bisacodyl
• Polyethylene Glycols

Topics

• Adult
• Bisacodyl (administration & dosage)
• Defecation (drug effects)
• Drug Carriers
• Humans
• Male
• Paraplegia (physiopathology)
• Plant Oils
• Polyethylene Glycols
• Suppositories
• Time Factors